Process Engineer, Ex Vivo T-cell Process Development

Location
Cambridge, MA, United States
Posted
Sep 22, 2020
Ref
777059785
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia is seeking a motivated Process Engineer to join our T-cell Process Development team, supporting ex vivo programs. The primary responsibilities for this position include process unit optimization and scaling of procedures for editing T-cells using CRISPR/Cas9, across multiple programs. In addition, the role will involve participation in process tech transfer to an external CMO, including MBR/SOP review and training. The ideal candidate will be familiar with cell-mediated immunity, T-cell receptor diversity, and assays to study T-cell related oncology tools.

Responsibilities:
    • Contribute to the design, development, and optimization of a functionally closed-system process for the manufacture of genetically modified T-cells for the treatment of cancer in collaboration with project lead.
    • Design and execute complex small and full-scale experiments involving the isolation, expansion, and cryopreservation of primary T-cells.
    • Optimize gene editing procedures in primary T-cells using the CRISPR/Cas9 system, including material transfer.
    • Assist in tech transfer of process to external CMOs, which may require hands-on training and site visitation.
    • Contribute to cell-based assay development by designing experiments, screening reagents, and troubleshooting critical parameters.
    • Interact cross functionally in order to effectively support early-stage development of product candidates, presenting data across multiple teams.
    • Write SOPs, technical reports, and maintain a highly detailed electronic lab notebook.
    • Stay informed of recent advances in the field of cell therapy by reading scientific journals and potentially attending conferences.


Minimum Qualifications:
    • Bachelor's degree in Chemical Engineering, Biomedical Engineering or related engineering discipline with 5+ years of hands-on experience or master's degree with 2+ years.
    • Previous hands-on experience with large scale closed system cell processing equipment such as CliniMACS, Sepax, Rotea, Prodigy, and Xuri bioreactors is highly desirable. Experience with clinical scale cell therapy manufacturing equipment preferred.
    • Process flow design, SOP drafting and review, and development report drafting, required.
    • Demonstration of aseptic cell culture techniques, including cell banking and expansion.
    • Ability to work effectively with management, process and analytical development, and supply chain to aid in sourcing reagents; and evaluating multiple vendors to inform process decisions.
    • Self-motivated with a passion for bringing life changing therapies to patients.
    • Willingness to acquire new skills and ability to work with minimal supervision.
    • Ability to communicate effectively with strong writing skills, and thrive in a team with time critical objectives.


Preferred Qualifications:
    • Previous experience in flow cytometry, including data analysis in FlowJo and cytometer operation preferred.
    • Familiarity with gene editing techniques, including electroporation and transduction.


#LI-KO1

What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .