Associate Director Clinical Pharmacology

Location
Princeton, NJ, United States
Posted
Sep 21, 2020
Ref
R1527114
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Associate Director, Clinical Pharmacology Pharmacometrician

Position Summary / Objective

he Clinical Pharmacology and Pharmacometrics (CP&P) team at BMS is responsible for the pharmacology and pharmacometric support for all pipeline assets throughout the clinical development lifecycle. Composed of pharmacologists, pharmacometricians, and modelers, this group oversees the pharmacokinetic evaluation, pharmacometric exposure-response evaluation, quantitative systems pharmacology modeling, physiologically based pharmacokinetic modeling and model based meta-analysis of assets covering all platforms of therapies, including small molecules, traditional and complex biologics and next gen cell therapies. All therapeutic areas are supported.

The CP&P team interacts with discovery and translational scientists, project leadership, early development, late development and commercial colleagues to optimize dosing, formulation, delivery and combination strategies to enable faster and more effective drug development informed by core scientific principals and data.

Scope of role:

  • Serve as a MIDD subject-matter-expert (SME) for a therapeutic area, and contribute to the planning and implementation of MIDD components of the clinical development plan for assets in the therapeutic area
  • Represent PMx in MIDD related health authority interactions
  • Accountable for the planning, execution, and reporting of formal PMx analyses supporting health authority submissions and interactions for a therapeutic area
  • Contribute to exploratory PMx analyses supporting internal drug development decisions
  • Responsible for ensuring that formal PMx activities are adequately resourced, by leveraging internal and external resources
  • Responsible for the quality and timely delivery of formal PMx reports
  • Collaborate with internal and external experts to develop innovative PMx methodologies that refine MIDD approaches
  • Lead and contribute to initiatives to maintain and enhance PMx infrastructure
  • Provide mentorship and guidance to colleagues in CP&P, particularly with respect to PMx


Requirements:

  • A PharmD or PhD in pharmaceutical sciences, pharmacology, biomedical engineering, or a related field.
  • 5+ years of experience in clinical pharmacology and pharmacometrics, including experience in characterizing the pharmacokinetic and pharmacodynamic (biomarker/safety/efficacy) properties of small molecule and biologics drugs
  • Deep experience in MIDD, as well as experience in planning and implementing MIDD components in clinical development plan.
  • Extensive experience in PMx analyses.
  • Strong written and oral communication skills necessary to report on and deliver scientific presentations
  • In-depth knowledge of current practices and issues in clinical pharmacology and pharmacometrics
  • Demonstrated the ability to work in a dynamic team oriented environment
  • Proficiency in the following software tools: R NONMEM, and MONOLIX
  • Strong written and oral communication skills necessary to report on and deliver scientific presentations
  • In-depth knowledge of current practices and issues in clinical pharmacology and pharmacometrics
  • Demonstrated the ability to work in a dynamic team oriented environment


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.