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Senior Scientist / Scientist, In Vitro Pharmacology

Employer
Maze Therapeutics
Location
South San Francisco, CA, United States
Start date
Sep 21, 2020

View more

Discipline
Science/R&D, Biotechnology, Pharmacology
Required Education
Masters Degree/MBA
Position Type
Full time
Hotbed
Biotech Bay, NextGen Bio

Job Details

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we'll develop for a range of severe diseases.

We are seeking an experienced, highly motivated scientist with small molecule expertise and significant experience developing key biochemical and cell-based functional assays to drive lead optimization for programs across the portfolio. The successful candidate will develop and perform medium and high throughput screening campaigns to collect compound activity data critical for early hit identification and lead optimization. Adaptability to a startup environment is fundamental to the role, as you will play a significant role in compound assessment and generating key datasets for development candidates.

Your Role in Navigating the Maze:
  • Develop, optimize and execute medium and high throughput screening campaigns to measure small molecule activity
  • Work alongside automation and research infrastructure to develop production assays for data collection
  • Implement in vitro models to determine on-target and off-target potency
  • Characterize activity in detailed biochemical, cell or tissue-based functional follow-up assays across varied target classes
  • Evaluate novel assay technologies for potential internalization or deployment with CROs
  • Manage, process, analyze and present data to project teams
  • Assist with the coordination of studies with CROs as necessary

Your Navigation Tools:
  • MS/PhD in relevant field with 5+ years' experience performing in vitro studies to measure compound activity
  • Experience with small molecule assay development, optimization and screening
  • Comprehensive working knowledge of biochemical/biomolecular and cell-based assays to interrogate targets
  • Demonstrated understanding of automation as it relates to production assays
  • Experience with mammalian cell culture
  • Solid knowledge of pharmacology concepts including potency, PK, physiological endpoints
  • Motivation to work on multiple project simultaneously and serve project teams to advance lead optimization programs
  • Excellent communication skills and ability to work in a team-based environment
  • Hands on, detail oriented and highly organized

Company

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
 
What are genetic modifiers?
 
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
 
The Maze approach
 
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
 
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
Website
Location
171 Oyster Point Blvd, Suite 200
South San Francisco
CA
94080
United States

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