Scientist, Delivery and Editing Technology - Cell Therapy

Location
Seattle, WA, United States
Posted
Sep 18, 2020
Ref
R1527671
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and BMS's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible.

The Cell Therapy Process Sciences and Technology team is seeking an individual to join its innovative, multi-disciplinary team focusing on non-viral, formulation-based gene delivery technologies. As a member of the Delivery and Editing Technology team, the individual will support the advancement of the T-cell engineering technologies for manufacturing immune-therapeutic products. This role will provide a challenging but rewarding opportunity for career development. A successful candidate is required to be well-versed in lipid/polymer-based formulation and screening, and aware of the limitations in ex-vivo and in-vivo applications.

Education and Experiences
  • PhD in Bioengineering, Chemical Engineering, Chemistry, Materials Science, or related discipline with 2+ years of relevant postdoctoral or industrial experience


Expertise and Skills
  • Strong expertise in non-viral nucleic acid delivery using at least one of the following drug delivery systems: lipid nanoparticles (LNPs), synthetic polymer-based drug delivery systems, polymer and/or lipid transfection reagents, nanoparticle functionalization and targeting
  • Deep understanding of cellular uptake mechanisms related to non-viral nucleic acid delivery
  • Extensive experience with transfection of mammalian cells; experience with primary cell types (PBMCs, T cells, stem cells, etc.) is a plus
  • Knowledge of gene integration technologies (transposons, gene editing via homology-directed repair, etc)
  • Familiarity with flow cytometry analysis
  • Familiarity with statistical design of experiments (DoE)


Duties and Responsibilities
  • Managing research project
  • Executing experimental plans
  • Data-driven decision making and troubleshooting
  • Strategic planning with alignment to higher level goals
  • Coaching junior members
  • CRO/CMO and vendor management
  • Cross-functional communications and collaborations


If you want to challenge yourself, accelerate your career, and give new hope to patients, there's no better place than here with our Cell Therapy team. Full of incredible and dedicated team members, those working on CAR-T and other forms of Cell Therapy are transforming patients' lives through science. From studying individualized cell lines to making brand new discoveries, this bold and personal discipline allows you to grow your career while making a lasting impact on the field of medicine. Join us today.

BMSCART

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.