Scientist

Employer
Abalone Bio
Location
Emeryville, CA
Posted
Sep 17, 2020
Ref
AB-SCI09172020
Required Education
Doctorate/PHD/MD
Position Type
Full time

We are looking for a talented molecular biologist and biochemist to work on Abalone Bio’s yeast-based antibody discovery technology platform. Projects will include antibody discovery, optimization,  production and characterization with in vitro and in vivo assays.

 

We are looking for someone who:

  • Thrives in a dynamic and demanding startup atmosphere
  • Loves handling multiple projects
  • Manages time and prioritizes well
  • Keeps careful records
  • Is enthusiastic and self-driven
  • Relates well and productively with others

     

 

Someone aligned with our core values:

 

  • Empathy      Listen actively, assume goodness
  • Collaboration    Solve problems together
  • Honesty    Be sincere and open
  • Kindness    Be generous and considerate
  • Gratefulness   Value the opportunity to do good
  • Continuous improvement    Become a little better every day

 

What do we offer?

An exciting science environment, led by accomplished scientist founders. An ambitious project that delivers a new class of antibody drugs with enormous potential. A supportive first-rate research team.

  • Competitive compensation and benefits.
  • Salary commensurate with qualifications, and stock options.
  • Health, dental and vision coverage, medical and parental leave, vacation and a retirement plan.

 

Location

Our facilities are in Emeryville, in the San Francisco Bay Area.

 

 

Environment

The Scientist will join a 6-8 person cross-functional R&D team.

At least weekly, the full team discusses experimental results, future plans and priorities.

Managers regularly hold one-on-one meetings to hear every team member’s concerns and thoughts, discuss and set clear expectations, and provide constructive feedback.

Work in the time of COVID: We have the privilege of being considered essential workers. We take the safety of our team and our responsibilities to the outside community seriously. We have just moved into a 5,000 square foot private space in Emeryville, CA that we laid out with COVID-19 risk mitigation in mind. The lab spaces are partitioned into smaller rooms for 1-3 people. We have also designated a number of small private spaces for team members to relax without a mask, and we are building more.

 

Qualifications/Experience

Required:

  • PhD degree
  • Extensive, hands-on recombinant DNA experience
  • 5 or more years of hands-on wet lab experience

 

Areas of expertise:

The ideal candidate has substantial first-hand experience in all of these areas:

  • Classical and modern genetic and strain engineering techniques (cloning, Gibson, CRISPR, in vivo homologous recombination, etc.), ideally in S. cerevisiae
  • Yeast functional assays, including growth, microscopy and flow cytometry
  • Biochemical assays (ELISAs, other plate-based kits and assays)
  • Antibody library design; antibody engineering, production, and purification
  • GPCR signaling, G proteins, and related science

     

 

Additional experience in the following is strongly preferred:

  • Recombinant protein purification and analysis
  • Mammalian cell culture, engineering, and cell-based assays
  • Antibody discovery techniques, especially phage or yeast surface display
  • Bioinformatics, NGS sequencing and analysis.
  • Computational skills, including data analysis using R or Python; shell scripting; development of new computational workflows

 

Job Description And Specific Responsibilities:

 

Core activities: