Senior Research Associate - In Vivo Pharmacology

JOB PURPOSE

This position will report directly to a scientist in the In Vivo Pharmacology group within the department of Pharmacology and Toxicology. The Senior Research Associate (SRA) will have three primary responsibilities: (1) to execute in vivo studies to support gene therapy and cell therapy research programs at Sana, via close collaboration with other members of the IVP team, (2) to carry out cell and tissue preparation work related to in vivo studies, and (3) to support needs across the Pharmacology and Toxicology organization. The position will also require close communication and collaboration with research groups at Sana outside of the Pharmacology and Toxicology organization.

DUTIES AND RESPONSIBILITIES

• Work closely with the Scientist and current in vivo coordinator to plan and execute in vivo studies in support of cross-functional groups
• Tissue collection and processing for downstream assays such as flow cytometry
• Support in vitro work (e.g. cell culture) to enable in vivo studies
• Due diligence on data recording, analysis and reporting using proper software (e.g.Graphpad Prism, Softmouse, FlowJo), electronic notebook, and data storage room
• Presentation of data to the team
• Participate in creating a collaborative, rewarding work environment

QUALIFICATIONS

Required Qualifications

• BS in biology or related discipline with 4+ years/MS with industry/academic experience
• Proficiency with standard molecular biology and cell biology techniques: RNA isolation and reverse-transcription, qPCR, mammalian cell culture, staining for Flow Cytometry and Lentivirus transduction
• Demonstrated experience with relevant software: Microsoft Word, Excel, PowerPoint, Graphpad Prism, FlowJo software
• Experience in developing in vitro and in vivo assays and deploying at scale in a collaborative research environment
• Extensive hands-on experience with the isolation and culture of mammalian cell lines and primary cells
• Demonstrated competence in sterile cell culture technique
• Proven ability to troubleshoot technical and scientific issues
• Strong interpersonal skills and adaptable communication style
• Strong organizational, record keeping, and data documentation skills
• Excellent oral and written communication skills, attention to detail and data quality, and experience working on diverse collaborative teams
• Willingness to work under adverse situation (e.g. COVID 19)

Preferred Qualifications

• BS or MS degree in immunology
• Experience with immune cell profiling using flow cytometry techniques
• Experience in working with mice: handling, injections (IV, IP, SC), bleeding, tissue harvest