Research Scientist, TCR Discovery

Kite Pharma
Gaithersburg, MD, United States
Sep 17, 2020
Required Education
Position Type
Full time
Kite is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the health and safety of our teams.

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job

Job Description

Everyone at Kite is grounded by one common goal - curing cancer. Every single day, we seek to establish a direct line between that purpose and our day-to-day work. Join us in our mission!

We are seeking a highly motivated individual to join our Solid tumor TCR-T program as a Research Scientist in our new Research, Development, Manufacturing, and Clinical facility (RDMC-East) in Gaithersburg, Maryland. The RDMC-East is being developed as a Center of Excellence for the advancement of novel TCR mediated T cell therapies targeting tumor mutations and antigens.

Reporting to a Director, the individual will lead projects and perform experiments to discover good quality TCRs against wide-ranging shared tumor antigens, evaluate efficacy and safety with the goal to implement them into our therapeutic platforms. In addition, he/she will investigate several engineering features to potentiate the T-cell activity in a variety of in vitro / in vivo experiments.

Responsibilities include, but are not limited to:

  • Develop, lead and manage projects involving isolation of TCR specific against novel tumor antigens
  • Isolation of primary human immune cells (T cells, B cells, Dendritic cells and other) from human blood and tumor material
  • Aseptic culture techniques of the tumor, T cells, and cell lines
  • Isolation of candidate TCRs using single-cell techniques
  • Evaluation and detection of T cell populations for their characteristics using flow cytometry-based assays;
  • Viral vector-based or electroporation-based modification of tumor cell lines and primary immune cells
  • Taking charge of routine tasks relating to laboratory operations (e.g., organization and maintenance of lab supplies)

Candidates with any of the following educational and technical skillset are encouraged to apply.

  • A Ph.D. in Immunology, Biomedical Sciences, Bioengineering, or Biotechnology (or related field) with 0-10+ years of experience is required. Your experience may be in academia, non-profit, or industry.
  • Immunological techniques such as isolation of T cells, mixed lymphocyte culture, cytotoxic killing assay, functional assays using FACS, ELISA, and other methods, in vivo mouse model experiments, etc. is essential.
  • Extensive hands-on experience and knowledge in Molecular Biology is a clear plus
  • Expertise in high-throughput technologies, such as genetic screenings using RNAi, Cas9 or engineered nucleases, single-cell technologies is an advantage but not a strict requirement
  • Strong verbal, written communication and analytical skills in English and ability to communicate results to a diverse cross-functional audience
  • Proactive, self-motivated team player with strong interpersonal skills, appropriate sense of urgency and the ability to work independently
  • Ability to work in a fast-paced environment with challenging work-load and to quickly get acquainted with novel methods and approaches
  • Thorough and continuous literature survey to stay up-to-date with the latest development in the field is strictly preferred

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit Sign up to follow @KitePharma on Twitter at

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For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.