Scientist - Computational Biology

South San Francisco, CA, US
Sep 17, 2020
Required Education
Bachelors Degree
Position Type
Full time
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing our Translational Science focus with modern molecular and cellular science and pathology laboratories, designed to discover and develop valuable biomarkers in support of clinical programs.

The Clinical Biomarkers & Diagnostics (CBD) department at Amgen is looking for a highly motivated Computational Biologist with expertise in data science, infrastructure, statistical modeling, handling clinical data sets and a background in biology. The primary responsibilities would be analysis of biomarker data for the assessment of biological impact, biochemical coverage, patient stratification, and indication selection in Amgen's clinical development programs. This role will provide subject matter expertise and leadership in the data science domain across CBD. The job will involve working with biologists especially in immuno-oncology to leverage information on our targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics, GWAS, next-generation sequencing and other high-content databases. The candidate is expected to interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives. As such, strong communication skills are imperative. Data integration, management, visualization, analysis and presentation are anticipated to be a substantial component of this job and the candidate is expected to provide leadership and expertise in those domains. The features of leadership we value include the ability to be fully responsible for an analysis, compete intensely and win, respect and trust co-workers, and be communicative, collaborative and accountable.

Basic Qualifications
Doctorate degree
Master's degree and 4 years of scientific experience
Bachelor's degree and 6 years of scientific experience

Preferred Qualifications
  • PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Biology
  • Three or more years of relevant experience in the biotech or pharmaceutical industry and a proven track record of productivity
  • Excellent grasp of statistics or applied mathematics to analyze large-scale biological data sets such as those from Next-Generation Sequencing (NGS) platforms.
  • Excellent grasp of biostatistics
  • Familiarity with machine learning methods as they relate to NGS, GWAS, single-cell transcriptomics, or flow cytometry
  • Ability to translate biological and medical questions into analytical models providing actionable results
  • Programming experience in scripting languages such as Python & R, and good programming practices
  • Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers
  • Familiarity with assay development and qualification requirements for clinical trial support
  • Experience with HPC infrastructure, Cloud operations, scientific application development and data management
  • Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community
  • Enjoys working in collaborative team environment
  • Strong written and oral communication skills, self-motivation, independence and leadership

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

A Fortune 150 company operating in nearly 100 countries around the world, we invest in highly skilled, dedicated and collaborative individuals who are ready to contribute to our mission in meaningful ways and make a difference in the lives of our patients. That's why, as a member of our cross functional, cross discipline team, we provide you with valuable opportunities to broaden your experience and maximize your potential. Focused on the industry's most compelling scientific discoveries and housed within industry leading facilities within the heart of the world's leading biotechnology hub, our colleagues are growing our pipeline through groundbreaking innovations. We believe in rewarding those who do rewarding work and are committed to providing careers that can help turn the tide of serious, life interrupting illnesses.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.