AbbVie

Associate Scientist I/II, Toxicology

Employer
AbbVie
Location
Lake County, IL, United States
Posted
Sep 16, 2020
Ref
2006780
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

The Preclinical Safety department at AbbVie relies on the zebrafish model for some of its investigative toxicology research. We are seeking an independently motivated scientist to support these efforts. The successful candidate will design and conduct bioanalytical assays focused on a wide range of toxicological endpoints. The position will be responsible for study design and execution, data analysis and interpretation, and the reporting of results to the wider team. The position will also have some responsibility supporting histopathology and molecular toxicology assays that contribute evidence to other toxicology studies.

Detailed responsibilities
  • Consult scientific literature to help guide experimental design and to develop new methods to interrogate test article toxicity.
  • Prepare test article solutions under the guidance of a formulations expert.
  • Handle zebrafish embryos, larvae, and adults; expose the younger life stages to test article.
  • Using microscopy, video-tracking, spectrophotometry, qPCR, ELISA, and other techniques, establish the relative toxicities of drug candidates.
  • Collect samples for analysis of drug levels; complete forms for clear sample identification to be communicated to the DMPK team.
  • Analyze data using Microsoft Excel, Graphpad Prism, or other data analysis software; analyze images using imaging tools.
  • Support molecular biology efforts designed around investigative toxicology.
  • Under the direction of a histopathologist, prepare histology samples from fish toxicology studies.
  • Prepare clear and concise reports, either written or verbal, that convey the need and potential impact of the research, how it was conducted, and the results.

Qualifications

Basic Qualifications
  • Bachelors or Masters in a related scientific discipline and 0-3 (BS) or 0 (MS) years of laboratory-based experience is required.

Experience
  • The following skills are required: pipetting; light and fluorescent microscopy; Microsoft Excel, Word, and Powerpoint.
  • The following are strongly preferred: ELISA; PCR; spectrometry
  • The following are preferred: electron microscopy; histology; biomarker discovery; molecular biology e.g. DNA cloning and sequencing; CRISPR or other genome manipulation tool.

Job level will be commensurate with experience

Work activities
  • Light lifting (3 L fish tanks)
  • Bending
  • Repetitive pipetting


Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.