Principal Investigator - Immunohistochemistry/Translational Science
Arcus Biosciences was founded on the vision of creating new cancer therapeutics through the utilization of unexploited insights in immunology. The company was formed in 2015 by a group of seasoned researchers from the biotechnology and pharmaceutical industries. Arcus Biosciences is now a clinical-stage company, with 4 compounds (2 antibodies and 2 small molecules) being evaluated across 10 different clinical trials. Arcus also has a robust pipeline of preclinical and discovery programs that will continue to fuel the development pipeline. The recently announced multi-year broad collaboration with Gilead Sciences will greatly accelerate our clinical development activities and will create a unique professional opportunity for experienced individuals in all aspects of drug development, including translational science.
Arcus is a tight knit interdisciplinary team and the successful applicant will work closely among researchers with different technical backgrounds in biology, bioinformatics and with members of our clinical department. The position offers an unusual opportunity for professional development through cross-functional collaborations to gain in-depth exposure to industrial drug discovery and development from an experienced and proven team.
We have an opening for a Principal Investigator with expertise in immunohistochemistry to work closely with members of the Pharmacodynamics, Clinical and Bioinformatics teams to evaluate patient samples from Arcus' antibody and small molecule combination clinical studies. The successful candidate will have a well-established track record of assay development and must have experience working with CROs to implement IHC assays suitable for the clinical environment. Hands-on experience interacting with clinical sites and CROs to obtain FFPE tissue from clinical trial subjects is essential. The ideal applicant should also have previous experience working with pathologists to develop appropriate scoring methods, as well as demonstrated proficiency in developing novel immunohistochemical assays for transfer and validation in a CAP-CLIA certified laboratory. Familiarity with multiplex chromogenic and fluorescent IHC assays and quantification using image analysis programs is highly desirable. Conversance with DNA/RNA extraction of nucleic acids from FFPE tissue and the proper handling methods to ensure stability of nucleic acids in tissue would be an advantage. Preclinical experience evaluating target expression across mouse tumors would also be valuable.
The Principal Investigator will be required to present data regularly at project team meetings to inform key leadership decisions. This position demands unwavering attention to detail and strong organizational skills, coupled with aptitude and enthusiasm for collaborating, maintaining high quality data, and managing the integrity of our complex, integrated database of clinical trial datasets and sample records. Supervisory and mentoring experience is also required to manage more junior staff members to ensure technical specifications are carried out appropriately and on time to meet project timelines. Excellent oral and written communication skills are required, along with a solutions-based approach, flexibility, and the ability to focus and deliver on time-sensitive objectives.
The selected applicant will have a Ph.D. with experience in relevant life sciences disciplines and at least 8-12 years of experience, including significant time in industry. Alternatively, scientists with a BS or MS or equivalent degree and 12-15 years of experience, including substantial time spent in a fast-paced industrial environment, with background appropriate for this position will also be considered.