Principal Scientist - Computational Biology

South San Francisco, CA, US
Sep 12, 2020
Required Education
Bachelors Degree
Position Type
Full time
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is developing our Translational Science focus with modern molecular and cellular science and pathology laboratories, designed to discover and develop valuable biomarkers in support of clinical programs.

The Clinical Biomarkers & Diagnostics (CBD) department at Amgen is looking for a highly motivated Data Scientist with deep expertise in next-generation sequencing (NGS) platforms and data analysis, single cell (sc) platforms and data analysis, statistical modeling, clinical interpretation and reporting and some background in biology. This is a high-visibility, individual contributor role preferring experience within matrix environments representing the function and requiring the development of methods to support the entirety of the clinical portfolio at Amgen.

Who you are
  • Motivated, hands-on, analytical, detail-oriented, data and science-driven, independent and accountable, with a track record of productivity
  • Have demonstrated expertise in genomics, epigenomics and functional genomics within clinical settings
  • Have performed and enjoy in-depth hands-on computational/data analysis work associated with the identification and interpretation of genomic variants
  • Familiar with state of the art centralized and distributed NGS assays and their relative strengths
  • Familiar with variant call QC, annotation, effect prediction, and clinical annotations within a clinical setting
  • Experienced with HPC/Cloud-Ops
  • Expert in Python and/or R and associated data-processing and machine-learning frameworks and aware of good programming practices
  • Biology-driven, with a strong foundation in molecular biology/genetics; you are as comfortable discussing wetlab aspects of NGS assays as you are discussing data analysis
  • An excellent communicator with dynamic interpersonal skills, situational awareness and the ability to work in a multidisciplinary, matrix setting
  • Are comfortable representing your function within a matrix setting to deliver best value to programs in development
  • An excellent manager of multiple tasks in parallel
  • Have superior work ethics and strong motivation to positively impacting the lives of patients

Strongly Recommended:
  • Experience with single cell platforms and analysis of data
  • Experience with the development of therapeutic molecules
  • Degree in computer science/bioinformatics/computational biology/statistics
  • Experience in immunology

What you will do
  • Represent the clinical biomarkers & diagnostics team in Amgen program/portfolio teams as a biomarker analysis lead
  • Assess biochemical coverage, patient stratification and selection of indications in Amgen's early clinical development programs
  • Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives
  • Develop translational informatics analysis infrastructure to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trials
  • Develop innovative best-practices for the next generation of clinical bioinformatics, such as the utilization of ctDNA-derived tumor burden as a prognostic biomarker/surrogate end point
  • Work with biologists, especially in immuno-oncology, to leverage information on our targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics, GWAS, NGS and other high-content databases
  • Develop tools for data integration, management, visualization, analysis and presentation and provide leadership and expertise in those domains

Basic Qualifications
Doctorate degree and 3 years of related scientific experience


Master's degree and 6 years of related scientific experience


Bachelor's degree and 8 years of related scientific experience

Preferred Qualifications
  • PhD in Bioinformatics, Statistics, Computer Science, Biology
  • Three or more years of relevant experience in the biotech or pharmaceutical industry
  • A strong scientific background with training in genetics and a proven track record of productivity
  • A working knowledge of applied mathematics or statistics to analyze large-scale biological data sets such as those from GWAS or Next-generation sequencing platforms
  • Ability to translate biological and medical questions into analytical models providing actionable results
  • Programming experience in scripting languages such as Python & R
  • Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers
  • Familiarity with assay development and qualification requirements for clinical trial support
  • In depth understanding of genomic technologies such as, but not limited to, next generation sequencing and transcriptional profiling in clinical samples
  • Experience with HPC infrastructure, Cloud operations, scientific application development and data management
  • Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community
  • Outstanding communication skills including both oral and written presentation
  • Enjoys working in collaborative team environment
  • Strong written and oral communication skills, self-motivation, independence and leadership.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.