Bristol Myers Squibb Company

Director, Translational Research

Location
Redwood City, CA, United States
Posted
Sep 12, 2020
Ref
R1528605
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development group within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA. This individual will lead the Targeted Oncology, Immuno-Oncology, and Translational Stromal teams within the Translational Development group. These teams are dedicated to developing and delivering translational and biomarker strategies for oncology, immuno-oncology, and stromal programs from early discovery through First in Human POC. The Director will work with a multidisciplinary team to build deep, mechanistically driven translational packages. The Director will be accountable for delivering new drug candidates that are ready for first-in-human clinical trials, discovery and development of clinical ready patient enrichment strategies assays that will monitor target engagement, pathway impact and cancer cell fate, ensuring that such strategies are converted into fit for purpose assays in the clinical setting. The scope of responsibilities also spans to design, experimental execution and data analysis contributing to clinical translational assays for initial patient selection pharmacodynamic endpoints and pharmacodynamic (proximal and distal), stratification strategies, in alignment with clinical development objectives, as well as clinic-ready target engagement and pharmacodynamics biomarker assays for TME TRC programs. The Director will bring deep scientific experience with emphasis on Oncology/Immuno-Oncology biomarkers, in depth knowledge of oncology and clinical development perspective, and expertise in matrix-based management. The Director will oversee the integration of early translational research with clinical development.

Responsibilities:
  • Lead a team of 3 PhDs, serving as the key interface within the Translational Development team's clinicalBiomarker and Translational Strategy and the Technology teams as well as groups across the TME TRC, & also with external partners
  • Accountable for the teams establishing and executing scientific strategy for understanding drug candidate mechanism of action and building target engagement, receptor occupancy and pharmacodynamic readouts that can be measured in clinical trials.
  • Accountable for development of clinic-ready patient selection and PD assays.
  • Accountable for development of translationally relevant ex vivo/ in vitro models to interrogate tumor microenvironment interactions and to inform clinical responses.
  • Accountable for design of hypothesis-driven studies of human samples to inform pharmacodynamics, mechanism of action, and patient stratification/selection.
  • Oversee application of relevant techniques, including high parameter flow cytometry, MSD, Luminex, Nanostring, and NGS, to identify and evaluate biomarkers using clinical samples.
  • Manage in-house, collaborative or CRO-based research to support multiple projects.
  • Interface with clinical biomarker team to guide and develop biomarker strategy for clinical studies.
  • Effectively collaborate in highly matrixed organization to drive the advancement of therapeutic candidates.
  • Actively participate in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature.
  • Act as an expert resource for immuno-oncology and targeted oncology, train and develop direct reports in clinical translational approaches, introduce cutting edge methodologies, the development of novel assays
  • Play a key role in providing the relevant translational input to discovery and clinical translational projects as part of interdisciplinary teams comprising research biology, bioinformatics, histopathology, Non-Clinical Development (DMPK, safety), and genomics, to address the probability of technical success of new agents or combinations and demonstration of efficacy signal in patients.


Requirements:
  • MD, PhD or MD/PhD in Cancer Biology, Immuno-Oncology or equivalent advanced biology degree.
  • Experienced scientist with 10+ years of industry experience in oncology and immuno-oncology drug discovery and drug development process.
  • Documented experience in oncology/ immuno-oncology drug development, deep understanding of the role of translational research/medicine and clinical biomarkers in drug development, and working knowledge of all functional areas of drug development, including biology, clinical development, diagnostic development.
  • Experience in the design and generation of clinic-ready biomarker assays in oncology.
  • Deep experience in interrogating multi-parameter data sets including flow cytometry and Next-generation sequencing (bulk or single cell) to test translational hypotheses.
  • Experience working with primary human samples, including designing and conducting biomarker and/or mechanistic studies.
  • Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate, and accept calculated risks to make informed decisions.
  • Demonstrated ability to lead others through change by navigating ambiguity, creating the context, and engaging individuals.
  • Comfortable working in a fast-paced environment where speed is paramount.
  • Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets.
  • Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies and working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc.
  • Demonstrated ability of working effectively to influence stakeholders in a highly dynamic matrix organization such as BMS and the ability to grow new leaders and delegate key projects appropriately.
  • Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, & demonstrated scientific acumen and mechanistic understanding of disease biology.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.