Bristol Myers Squibb Company

Immuno-Oncology Stromal Discovery Biology Lead, Tumor Microenvironment Modulation TRC

Location
Redwood City, CA, United States
Posted
Sep 11, 2020
Ref
R1518974
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

(Senior Director/Director Level)

Position Summary

Reporting to the SVP of the Tumor Microenvironment Thematic Research Center (TME TRC), incumbent will provide scientific, business and strategic leadership for the stromal biology discovery efforts within the TME TRC. You will lead the stromal biology-associated portion (both small and large molecule) of the preclinical drug development programs for the TME TRC to help develop therapeutic targets at the intersection of stromal, tumor and immune biology to enhance responsiveness to checkpoint blockade and other targeted therapies.

Incumbent will have a strong scientific background in stromal biology, or closely related area, be familiar with drug development (biologics and/or small molecule) from target identification through to first in human studies, and have a proven track record in effectively managing and leading scientific teams. You will collaborate with both local and global bioinformatics as well as translational medicine colleagues to generate testable hypotheses for targetable tumor-associated stromal nodes and pathways within the tumor microenvironment that drive resistance to current immunotherapies.

Leadership Responsibilities:
  • Responsible for the scientific leadership and overall effectiveness of the stromal biology discovery group including providing strategic direction, development and implementation of work efforts within the group and managing resources within the group to meet the department goals.
  • Work closely with TRC Scientific Leadership group to deliver on pipeline from new target discovery, validation, therapeutic candidate selection through to first in human stage, including identification and assessment of external opportunities.
  • The incumbent will be responsible for the development of staff, and for fostering a collaborative workplace environment within the direct areas of responsibility and across different groups of stakeholders, on site and across BMS, to meet the TME TRC objectives.
  • As part of the TRC leadership team, the incumbent will be responsible for participating in setting of TME TRC goals, and contributing to, communicating and supporting, all site-wide initiatives to respective department.
  • Responsible for maintaining highest degree of scientific excellence and personal motivation for staff
  • Demonstrates leadership consistent with the BMS's philosophy, including attracting and retaining top key talent critical to business success, developing team members
  • Preferred experience with providing oversight into preparation of technical reports and nonclinical sections of documents to support IND filings and other regulatory documents associated with moving candidates from nonclinical to clinical environment


Managerial:
  • Direct management of group of ~7-10 people focused on tumor stromal biology discovery with responsibility for leading, mentoring and supporting career development
  • Provides strong leadership, clear direction, development opportunities and open communication to staff; employee development and cross training


Collaborations/team support
  • Responsible for integrating efforts of the stromal discovery group with relevant partners including those both internal and external to RWC and BMS
  • Responsible for effectively collaborating with other discovery and translational biology colleagues as well as colleagues in supportive line functions (including discovery biotherapeutics, small molecule drug discovery, translational medicine, early clinical development and project leadership) to advance preclinical development of therapeutic candidates to early clinical development


Requirements:
  • A PhD (or equivalent) in relevant area of tumor biology/immune-oncology with a strong background in stromal biology e.g. fibroblast biology, wound healing biology, suppressive stromal factors, and a minimum of 8 years of relevant experience in industry/biotech
  • Strong oral and written communication skills
  • Proven track record in managing teams and in moving programs from basic research through to IND-stage


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.