Bristol Myers Squibb Company

Associate Director of DMPK

Location
San Diego, CA, United States
Posted
Sep 11, 2020
Ref
R1529466
Required Education
Doctorate/PHD/MD
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

Position Summary:

We are seeking a highly enthusiastic, motivated, exceptional scientist as an Associate Director of DMPK in drug discovery at our San Diego site. The role is in the Pharmaceutical Candidate Optimization (PCO) department that encompasses broad support for Discovery programs with expertise in DMPK, toxicology, pharmaceutics and bioanalytical sciences.

In this role, the candidate will provide subject matter expertise on absorption, distribution, metabolism and excretion (ADME) for Discovery programs, and he/she will be responsible for designing mechanistic in vitro and in vivo studies to understand and resolve issues to drive discovery efforts. There will be a major emphasis on working with Discovery project teams specifically in San Diego, but the candidate will be expected to contribute to program science and strategy across the Discovery portfolio, with potential collaborations at our Redwood City, CA, Princeton, NJ and Cambridge, MA sites.

Requirements:

The position requires a Ph.D. in pharmacokinetics, drug metabolism, medicinal chemistry or related discipline with a minimum of 10 years of relevant industrial experience. At the Associate Director level, the candidate should have a proven level of evidence of leadership in DMPK science and proven track record of scientific achievement through project influence and publication. Experience with small molecule DMPK strategies is essential, and experience with biologics or other novel modalities is desired. A general understanding of PK/PD concepts and their applications to assessment of the pharmacologic profile of modalities is required, along with the ability to integrate data from multiple sources to understand the drug disposition of a molecule.

The ideal candidate will supervise a small group of research associates (3-5), must possess excellent oral and written communication skills, and be a good mentor for junior or non-ADME scientists. The ability to collaborate and build strong relationships with other disciplines in PPCO (discovery toxicology and Discovery pharmaceutics and bioanalytical research) for issue resolution and program advancement is essential.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.