In Vivo Pharmacology Research Scientist, Cancer Biology

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Job Description: In Vivo Pharmacology Research Scientist, Cancer Biology

We are seeking an In Vivo Pharmacology Research Scientist to join the Oncology Discovery Pharmacology and In Vivo Biology group within the Mechanisms of Cancer Resistance (MoCR) organization at Bristol-Myers Squibb Cambridge, MA.

The qualified candidate is a highly motivated, interactive, and creative bench scientist who will conduct experiments utilizing tumored mouse models to advance drug discovery programs from target identification/validation to early therapeutic candidates. The successful candidate will demonstrate clear and professional verbal and written communication, effectively collaborate with colleagues across a highly matrixed environment, and be capable of presenting scientific results to the Pharmacology team as well as the broader MoCR group.

Qualifications & Responsibilities

• 7 years of relevant industry experience minimum for BS.
• 4 years of relevant industry experience minimum for MS.

This is not a PhD role.

• Demonstrated record of leveraging in vivo pharmacology models to explore cancer biology and enable cancer drug discovery.
• Skilled and proficient at independently running tumored mouse studies to perform tumor model development, anti-tumor efficacy and PK/PD studies in conjunction with necropsy/tissue/blood collection.
• Skilled and proficient with subcutaneous xenograft tumor models and syngeneic models required. Experience with orthotopic models is a plus.
• Skilled at murine dosing via PO, IP, IV, SC routes.
• Proficiency in cell culture, passaging and harvesting cells is required. Prior experience with cell line engineering (transfection, lentivirus-mediated transduction) is desired but not required.
• Demonstrated experience with the following ex vivo techniques is highly desired: tumor dissociation, DNA/RNA/protein extraction, qPCR, ELISA (MSD), WB.
• Working knowledge and hands-on experience with multi-color FACS is desired, however not required.
• Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required.
• Attention to detail with excellent organizational and record keeping skills is a requirement.
• Strong written and verbal communication skills with the ability to interact effectively with peers and management. Capable of presenting scientific results to multidisciplinary teams and key stakeholders.
• Ability to mentor junior associates and colleagues on best practices in the laboratory would be highly valued.
• Highly motivated and ability to be flexible in case of changing priorities.
• This position is located in Cambridge, MA.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.