Bristol Myers Squibb Company

Associate Scientist, Cellular Phenotype

Location
Seattle, WA, United States
Posted
Sep 09, 2020
Ref
R1529345
Required Education
Bachelors Degree
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

PURPOSE AND SCOPE OF POSITION:

The Cellular Phenotype (CP) team is seeking an Associate Scientist to lead development, qualification, transfer and life cycle management activities for novel flow cytometry analytical methods to support process development and clinical release for early and late stage cell therapy programs. The CP team is responsible for developing, qualifying, automating, transferring and supporting method life cycle for both characterization and clinical release methods early and late stage cell therapy programs. Individuals in this role will interact cross-functionally with process and analytical development organizations to align analytical strategies and timelines, develop and execute flow cytometry assay needs. Interaction and mentorship of junior scientists is required, including technical wet-lab and analytical training and review of development and routine analytical results. The Associate Scientist will also independently support method development and qualification execution in the lab.

Successful candidates will have a strong foundation in immunology and a variety of immunological methods. This role is highly collaborative and requires a demonstrated ability to coordinate projects with cross-functional teams and independently design and execute studies to meet project goals.

REQUIRED COMPETENCIES: Knowledge, Skills, and Abilities:

Education:

A Bachelor's or Master's in a scientific discipline with 7-10 years of relevant industry experience

Experience

Qualifications and Education Requirements
  • Proven ability to work in a high paced team environment, meet deadlines, & prioritize work on multiple projects.
  • Strong foundation in immunology and/or cell biology including experience with primary immune cells.
  • Demonstrated experience with development and execution of polychromatic (13-plus color) flow cytometry panels
  • Thorough and demonstrated understanding of flow cytometry instrumentation and software such as Flow Jo, FACS Diva, and FCS Express

Preferred Qualifications
  • Experience with method qualification or validation
  • Thorough understanding of immunology and cell-based assays as applied to the cell therapy field
  • Experience with functional assays using primary human T-cells
  • Assay development (flow cytometry, bead-based multiplexed platforms, ELISA, cell killing assays)
  • Experience with cellular cryopreservation protocols
  • Experience with migrating established assays to automated liquid handlers
  • Successful track record of prioritizing work across multiple projects


DUTIES AND RESPONSIBILITIES:
  • Independently develop flow cytometry panels for implementation into early and late development programs
  • Execution of phase appropriate flow cytometry method qualification
  • Provide ongoing analytical support of transferred methods
  • Assist and train users within the department on method execution, data analyses, and proper use of instrumentation
  • Transfer of developed flow cytometry method onto established automation system
  • Titrate and maintain antibody stocks, as needed


WORKING CONDITIONS (US Only):
  • Work will be conducted in office and laboratory environments with a mix of natural and LED lighting with low level background noise Personal protective equipment (PPE) must be worn at all times when in the laboratory, including but not limited to lab coats, protective eye gear, and disposable gloves. Work environment may include extended time working in biosafety cabinets and liquid nitrogen storage containers. Physical activity involves moving between wet-lab stations to execute experimental plans, moving up and down stairs or elevators to access equipment or materials on other floors, and may involve lifting containers (usually
  • 40% time seated desk work with ergonomic working spaces and sit/stand desks; 60% time in laboratory or meetings.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.