Bristol Myers Squibb Company

Principal Scientist, Immune Oncology and Cellular Therapy Translational Development

Location
Seattle, WA, United States
Posted
Sep 07, 2020
Ref
R1525675
Required Education
Doctorate/PHD/MD
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Principal Scientist, Immune Oncology & Cellular Therapy Translational Sciences

We are looking for a talented principle scientist to be part of the translational research group based in Seattle. Responsibilities of this role are to act as the global project team translational lead for a key cellular therapy asset, mentor junior translational scientists, to align translational strategy and research for their program across indications and studies, and review and apply translational learnings within the group and cross-functionally by engagement of key stakeholders. Expertise in developing and qualifying biomarkers for clinical trials, and strong knowledge in immunology and tumor biology is required.

Responsibilities:
  • In-depth knowledge of fundamentals of immunology, immune oncology, and/or tumor biology in hematological malignancies
  • Utilization of translational based approaches to develop new concepts and mechanism of action hypotheses, and identifying distinguishing pharmacodynamic characteristics of compounds alone and in combination with other therapies
  • Knowledge of biomarker discovery and development: assay development/validation, clinical discovery of biomarkers, MoA research, knowledge of platforms
  • Experience and knowledge of CART therapies and translational challenges
  • Design and execution of primary immune cell-based assays
  • Supervise scientific and technical staff
  • Manage internal projects in immune oncology drug development
  • Serve on internal project teams and committees as scientific functional lead
  • Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics.
  • Understand the context, impact and timely communication of data


Specific Duties:
  • Implement in-vitro immunologic assays for evaluating activity and mechanism of action of immune oncology drug candidates using primary cell cultures and patient samples
  • Develop in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
  • Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps
  • Supervise Scientists and Associate Scientific staff
  • Participate in team meetings to present data and provide interpretation
  • Establish and maintain working relationship with contract laboratories and relevant academic collaborators
  • Ensure that the group maintains current awareness in area of expertise, enhance the scientific credibility of Bristol-Myers Squibb through contributions to the scientific literature (publications/presentations)
  • Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate


Qualifications:
  • Ph.D. degree in immunology, tumor biology or cellular biology, or pharmacology with at least 3 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 10 years of successful experience as a scientist in the biotechnology or pharmaceutical industry setting
  • Excellent communication and interpersonal skills demonstrated in a team environment
  • Expertise in developing biomarkers for clinical trials, and strong knowledge in immunology and tumor biology, knowledge of hematopoietic malignancies desired
  • Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, methylation specific PCR)
  • Familiarity with data management tools and software for analyzing translational data sets from various assay formats. Biological interpretation of high content data sets in collaboration with computational biology
  • Effective team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.