Bristol Myers Squibb Company

Research Investigator, In Vivo Pharmacology Oncology

Location
Redwood City, CA, United States
Posted
Sep 07, 2020
Ref
R1527347
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

We seek an experienced, creative Research Investigator in the field of Immune-Oncology/Oncology to join our In Vivo Pharmacology team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, California. The successful candidate will play an essential role in the development of advanced models of cancer and the discovery of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology.

You will actively participate in our pre-clinical drug discovery and development projects, implement new cutting-edge in vivo models of cancer, plus create and execute in vivo strategies. A wide range of animal models including syngeneic, GEM, CDX, PDX and humanized tumor models will be utilized. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work in a multi-functional team environment. You will gain and provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation, to IND enabling activities and ultimately to clinical Proof of Concept in patients. You will characterize and develop small and large molecule therapeutics in close collaboration with your colleagues within in vivo pharmacology and partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams. Ideal candidates will have a strong background in characterizing the tumor microenvironment and possess excellent communication skills with a strong commitment to scientific objectivity and excellence.

Responsibilities:
  • Design and conduct in vivo studies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
  • Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates. Advanced in vivo cancer models include syngeneic, genetically engineered mouse (GEM) and humanized tumor models.
  • Compliance with IACUC and AALAC regulations.
  • Interpretation, documentation and presentation of experiments within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


Qualifications and Requirements:
  • PhD in cancer biology, immunology or a related discipline and demonstrated expertise in the tumor microenvironment, oncogenic signaling pathways or immuno-oncology is required. At least 0-4 years of relevant industry experience required.
  • Industry and/or translational drug discovery experience is a plus.
  • Expertise in multi-parameter flow cytometry analysis of tumor infiltrating immune cells (Cytobank, FlowJo, MACS).
  • Expertise in in vivo pharmacology and experience with animal models of human cancers as well as strong publication record or evidence of equivalent achievements in industry are desired.
  • Excellent interpersonal and communication skills to interact effectively with internal and external colleagues fostering a collaborative workplace environment.
  • Hands on in vivo skills (dosing, tissue/blood collection, surgery).
  • Expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA, scRNAseq, organoids is a plus.
  • Competitive candidates are expected to have a strong track record of independent and innovative research as evidenced by publications in top tier peer-reviewed journals.


Travel Required
  • Local and international travel for conferences and meetings may be required depending on project needs up to 5-10% of the time.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.