Senior Research Investigator, Early Development Predictive Sciences

Location
Cambridge, MA, United States
Posted
Sep 07, 2020
Ref
R1524066
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking an innovative scientist to join our Early Development team within the Informatics and Predictive Sciences group. This scientist can work in either of the following locations, Cambridge MA or Lawrenceville NJ. This group of computational biologists is responsible for advancing Bristol-Myers Squibb's industry-leading Early Development pipeline through the strategic application of cutting-edge bioinformatics approaches. The scientists in this group design experiments and analyze both pre-clinical and clinical-omics data sets, including RNA-Seq, exome, single-cell sequencing, cytokine, metabolomics and multiplex flow cytometry to develop patient enrichment strategies, novel biomarkers, diagnostics and guide drug development decisions. The group interacts with and influences all aspects of R&D at BMS, from early discovery through late-stage development.

Informatics and Predictive Sciences (IPS) has a mission to drive predictive informatics research across BMS, with focus on Research & Early Development, Clinical R&D and GPDO. The role of IPS encompasses a broad range of computational research, from cutting-edge bioinformatics to discover new therapeutic targets, to applied machine learning to optimize clinical trials and predict patient outcomes. The Early Development Predictive Science team focuses on cutting edge informatics research to progress BMS' Early Development clinical pipeline.

Responsibilities

Analysis of omic datasets including RNASeq, WES, single cell sequencing, cytokine and multiplex flow cytometry to inform trial design, enable patient enrichment strategies and early stage clinical development of the BMS Cardiovascular, Fibrosis and Immunology (ICF) pipeline. Collaborate with other bioinformaticians, statisticians, biologists and clinicians to implement and execute bioinformatics analysis to impact our Early Development ICF pipeline.

Qualifications:
  • Ph.D. in bioinformatics, molecular biology, statistics, physics, genetics, or similar
  • 3+ years of industry experience
  • Broad experience with data generated by one or more high-throughput molecular assays: next-generation sequencing, metabolomics, flow cytometry, mass spectrometry proteomics, etc.
  • Strong experience in the use of a high-level programming language such as R, MATLAB or Python for complex data analysis and reproducible research practices
  • Strong problem-solving and collaboration skills, rigorous and creative thinking
  • Exceptionally strong communication, data presentation and visualization skills.
  • Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects
  • Proven ability to work across organizations to define and solve problems that will benefit the whole.
  • Capable of establishing strong working relationships across the organization.
  • Background in cardiovascular disease, fibrosis or immunology and experience working with clinical trial data a plus
  • Strong publication record


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.