Senior Scientist I, DMPK

Sunnyvale, CA, United States
Sep 06, 2020
Required Education
Masters Degree/MBA
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

General Position Summary/Purpose:

The DMPK-BA department at Sunnyvale, CA is seeking a motivated Scientist to join the biotransformation group. The responsibilities include biotransformation in vitro/in vivo assays and understanding the SAR for lead optimization. A strong background in delineating hepatic and extrahepatic biotransformation pathways and structural elucidation by LC-MS is required. Work closely with bioanalytical, in vitro ADME, and PK scientists to integrate metabolite identification data for drug discovery and development. Experience with in vivo preclinical and in vitro ADME assays and understanding of clearance route, mechanism and the role of metabolism is preferred.

Key Accountabilities/Core Job Responsibilities:

  • Good understanding of organic/structural elucidation chemistry, xenobiotic and extra hepatic metabolism is required
  • Promote awareness of scientific and technical developments in the field of electrophilic covalent/reversible drugs, apply them to exploratory programs to facilitate the discovery of promising next generation drug targets
  • Enzyme substrate/ inhibitor kinetics for CYP and non CYP pathways required
  • Be proficient with cell culture technique. Primary hepatocyte cell culture experience required.
  • Ability to execute new laboratory techniques essential for in vitro biotransformation for lead optimization in drug discovery
  • Proficiency in LC-MS method development for separation and structural identification of multiple metabolites from various matrices
  • Hands on experience in operation, maintenance & trouble shooting of LC-MS instruments of multiple vendors (Sciex/Thermo) and associated software's
  • Maintain accurate records and write reports for in-house studies


Education, Qualifications, and Experience Requirements (degree, certifications, etc.):

  • PhD degree, MS degree (8 years of experience), B.S. (10 years of experience), or equivalent in drug metabolism or related discipline with relevant industrial experience in drug discovery/development
  • Prior experience with HPLC and LC-MS are required. Experience with AB Sciex and/or Thermo Orbitrap high resolution mass spectrometry instruments are a must
  • The candidate must be able to analyze data and maintain detailed, accurate and comprehensible study documentation. Experience with various scientific data base is a plus
  • The individual is also expected to be organized, a team player, enthusiastic about drug discovery, and possess effective communication skills

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.