Senior Research Associate, Analytical Development

Sep 06, 2020
Required Education
Bachelors Degree
Position Type
Full time

Sana Biotechnology is looking for a highly-motivated individual to join a dynamic, rapidly growing, and collaborative team in the Analytical Development Group. This individual will be a part of the forefront of gene therapy approaches utilizing a novel biological platform, and he/she/they will support analytical characterization of viral vectors for in-vitro research-based experiments. The candidate will execute assay development and testing activities as well as cell process efforts that lead to a robust and scalable manufacturing process. The position represents an excellent opportunity for career development, working closely with experienced cell and gene therapy scientists in a highly collaborative environment.


As a member of the analytical development team, the individual will contribute to the development of Sana's scalable vector manufacturing process platforms through:
  • Developing, optimizing and executing robust and reproducible assays in support of both discovery research and pre-clinical development.
  • Supporting vector product characterization, such as functional titer, physical particle counts, particle aggregation, and infectivity.
  • As part of the bioprocess team, supporting process characterization, such as residual host cell protein and DNA assays.
  • Generating and maintaining various cell lines used by gene therapy process development and other internal research teams for vector production.
  • Coordinating with various internal groups for evaluation of emerging vector products.
  • Implementing superb documentation of procedures and experiments to support tech transfer.
  • Contributing to and being a part of Sana's mission and culture.


Basic Qualifications
  • B.S. or M.S. in molecular biology, biochemistry, protein chemistry, virology or related discipline with 3 years of relevant experience.
  • Prior experience in development and execution of assays to characterize and measure proteins and DNA using a variety of methodologies including flow cytometry, qPCR, ddPCR, electrophoresis, ELISA, and imaging.
  • Experience with adherent and/or suspension mammalian cell culture, such as CHO, HEK293, or similar cell lines.
  • Excellent bench skills with attention to detail and high standards for data integrity and quality.
  • Able to critically analyze data and troubleshoot methods and equipment.
  • The candidate should be a team player, highly organized with excellent communication skills, and demonstrate scientific rigor and excellent problem-solving skills.

Preferred Qualifications
  • Experience with cell-based viral titration assays (e.g. flow cytometry, PCR, ELISA).
  • Experience with viral vector systems, production and/or purification.
  • Experience with liquid handler automation platforms (e.g. Integra, Hamilton, Tecan)
  • Familiarity with GxP principles and regulations as demonstrated by technology transfer to GxP manufacturing, GxP clinical manufacturing, or significant laboratory support of IND/BLA submissions.

  • Flexibility to work some evenings or weekends in support of cell culture processing
  • Ability to travel


Ability to perform assays, standard cell culture in a development lab.