Principal Research Associate, Cell Line Development

South San Francisco, CA, United States
Sep 06, 2020
Science/R&D, Research
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

The candidate will be responsible for developing stable producer cell lines for clinical and commercial viral vector manufacturing. She/he should have strong expertise in molecular/cell biology, mammalian cell culture and gene editing.

  • Design expression constructs for cell line engineering
  • Generate and characterize stable cell lines to support clinical/commercial production for therapeutic programs
  • Use molecular/cell biology, biochemical and process development methodologies to optimize the cell line development platform to improve yield, product quality and speed
  • Incorporate the use of automation and data science/informatics to execute and manage the cell line development workflow
  • Lead technical projects and collaborate with individuals on cross-functional teams
  • Meticulous documentation of experimental results and methods in electronic lab notebook
  • Author technical reports and relevant sections of INDs and BLAs
  • High proficiency in articulating experimental results at functional and cross-functional project team meetings


Basic Qualifications
  • B.S. in a Molecular Biology, Cell Biology or related field, with 6 years of experience or M.S. with 4 years of experience
  • Expertise in mammalian cell culture, molecular biology and viral biology, including adherence to rigorous standards of good lab practices, safety, and documentation
  • Independently and proactively design/execute experiments and analyze/interpret data
  • Effectively collaborate with individuals across multiple sites and participate on cross-functional teams
  • Excellent verbal and written communication and organizational skills

Preferred Qualifications
  • Hands on experience with automated liquid handlers and high throughput screening
  • Experience applying gene editing technologies to generate mammalian cell lines
  • Experience with cell culture process development, including use of DOE and small scale bioreactors