Principal Research Associate, Cell Line Development

Location
South San Francisco, CA, United States
Posted
Sep 06, 2020
Ref
4802552002
Discipline
Science/R&D, Research
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

The candidate will be responsible for developing stable producer cell lines for clinical and commercial viral vector manufacturing. She/he should have strong expertise in molecular/cell biology, mammalian cell culture and gene editing.

DUTIES AND RESPONSIBILITIES
  • Design expression constructs for cell line engineering
  • Generate and characterize stable cell lines to support clinical/commercial production for therapeutic programs
  • Use molecular/cell biology, biochemical and process development methodologies to optimize the cell line development platform to improve yield, product quality and speed
  • Incorporate the use of automation and data science/informatics to execute and manage the cell line development workflow
  • Lead technical projects and collaborate with individuals on cross-functional teams
  • Meticulous documentation of experimental results and methods in electronic lab notebook
  • Author technical reports and relevant sections of INDs and BLAs
  • High proficiency in articulating experimental results at functional and cross-functional project team meetings

QUALIFICATIONS

Basic Qualifications
  • B.S. in a Molecular Biology, Cell Biology or related field, with 6 years of experience or M.S. with 4 years of experience
  • Expertise in mammalian cell culture, molecular biology and viral biology, including adherence to rigorous standards of good lab practices, safety, and documentation
  • Independently and proactively design/execute experiments and analyze/interpret data
  • Effectively collaborate with individuals across multiple sites and participate on cross-functional teams
  • Excellent verbal and written communication and organizational skills

Preferred Qualifications
  • Hands on experience with automated liquid handlers and high throughput screening
  • Experience applying gene editing technologies to generate mammalian cell lines
  • Experience with cell culture process development, including use of DOE and small scale bioreactors