Senior Scientist I, Protein X-ray Crystallography

Lake County, IL, United States
Sep 05, 2020
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

The Protein Crystallography Group at AbbVie Headquarters in Lake County, Illinois is seeking a highly motivated scientist to join our Structure-Based Drug Discovery team. The ideal candidate should have extensive hands-on experience in modern X-ray Crystallography techniques and computational methods of molecular structure analysis. As part of multidisciplinary teams, the Scientist will utilize fragment-based strategies to identify ligands and provide insight to advance drug discovery targets through structure-based design. The successful candidate will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.

Key Responsibilities:
  • Determine X-ray crystal structures of protein-ligand complexes in high throughput modes and identify strategies for improved molecular designs.
  • Provide guidance to crystallization and protein construct design efforts for useful sample preparations
  • Utilize cheminformatics tools and manipulate scripts for use across mixed computing platforms
  • Interact with members of Fragment-based Drug Discovery team to advance hit to lead projects
  • Work with biologists, molecular modelers, and medicinal chemists to validate targets of interest
  • Maintain accurate and timely records of experimental results
  • Communicate results and interpretative analysis to project teams, and present at internal meetings
  • Publish in peer-reviewed journals as appropriate and present at external scientific meetings
  • Evaluate the scientific literature critically and adopt novel technologies which will facilitate structure-based drug discovery at AbbVie


  • BS, MS or PhD in Chemistry, Biochemistry, Biophysics, or a related field with typically 10+ (BS), 8+ (MS) 0+ (PhD) years of relevant academic or industry experience is required
  • Proven ability in protein crystallization and crystal structure analysis with X-ray or CryoEM/Electron Diffraction data
  • Familiarity with structure based drug design strategies and fragment based approaches
  • Experience in complementary techniques of macromolecular SAXS analysis or CryoEM is desirable
  • Must be detail oriented and meticulous regarding documentation and data management
  • Ability to work both independently and as part of a highly collaborative, interdisciplinary team
  • Effective written and verbal communication skills
  • Ability to work on multiple projects in parallel and rapidly adjust to changing priorities

Significant Work Activities
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.