Bristol Myers Squibb Company

Principal Scientist, Immune Oncology and Cellular Therapy Translational Development

Seattle, WA, United States
Sep 03, 2020
Required Education
Associate Degree
Position Type
Full time
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Principal Scientist, Immune Oncology and Cellular Therapy Translational Development

The candidate will be part of the translational research group based in Seattle and will have responsibility for directing the translational strategies of early clinical stage oncology drug development programs in immune oncology and cellular therapy from first in-human studies to proof of concept. Key responsibilities of this role are to act as the translational lead for the clinical programs and develop and execute translational strategies while working with translational scientists and cross-functional disease team and thematic research centers. Expertise in developing and qualifying biomarkers for clinical trials, and strong knowledge in immunology and tumor biology is required. Activities include carrying out mechanism of action studies, biomarker identification, and generation of data that supports patient stratification and the pharmacodynamic evaluation of drugs in the clinical setting.

  • In-depth knowledge of fundamentals of immunology, immune oncology, and tumor biology in solid and hematological malignancies
  • Utilization of translational based approaches to develop new concepts and mechanism of action hypotheses identifying distinguishing pharmacodynamic characteristics of compounds alone and in combination with other therapies
  • Knowledge of biomarker discovery and development: assay development/validation, clinical discovery of biomarkers, MoA research, knowledge of platforms
  • Design and execution of primary immune cell based assays
  • Supervise scientific and technical staff
  • Manage internal projects in immune oncology drug development
  • Serve on internal project teams and committees as scientific functional lead
  • Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics.
  • Understand the context, impact and timely communication of data

Specific Duties:
  • Implement in-vitro immunologic assays for evaluating activity and mechanism of action of immune oncology drug candidates using primary cell cultures and patient samples
  • Develop in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
  • Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps
  • Supervise Associate Scientist(s) and/or Research Associate(s) as needed, and under the direct, but limited supervision of management
  • Participate in team meetings to present data and provide interpretation
  • Establish and maintain working relationship with contract laboratories and relevant academic collaborators
  • Ensure that the group maintains current awareness in area of expertise, enhance the scientific credibility of Bristol-Myers Squibb through contributions to the scientific literature (publications/presentations)
  • Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate

  • Ph.D. degree in immunology, tumor biology or cellular biology, or pharmacology with at least 3 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 10 years of successful experience as a scientist preferably in the biotechnology or pharmaceutical industry setting
  • Excellent communication and interpersonal skills demonstrated in a team environment
  • Expertise in developing biomarkers for clinical trials, and strong knowledge in immunology and tumor biology, knowledge of hematopoietic malignancies desired
  • Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, methylation specific PCR) techniques
  • Familiarity with data management tools and software for analyzing translational data sets from various assay formats. Biological interpretation of high content data sets in collaboration with computational biology
  • Effective team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors
  • Detail-oriented with the ability to identify and implement creative solutions
  • Ability to prioritize and manage time efficiently

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.