Senior Research Scientist I, Toxicology

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Responsibilities:

• Create novel experimental designs for mechanistic toxicology studies designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions
• Support predictive toxicology experimental efforts within Discovery (e.g., in vitro cell-culture based, animal models of disease) analyze safety-related data and use it to make decisions.
• As a Discovery Working Group representative, develop early safety assessment, ensure appropriate toxicology studies and liability screens are performed to support nomination of drug candidates for further development.
• Participate in issue-resolution teams, where she/he will contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development.
• Communicate results clearly and concisely in both oral and written reports
• Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally).
• Closely interact with scientists in other functional areas.

Qualifications:

• A Ph.D. in toxicology is required, and postdoctoral experience is preferred, along with evidence of a strong publication record.
• This position will require broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity.
• This is mid-career position and at least 7 years of experience in the pharmaceutical industry is desirable.
• Equivalent years of experience in an academic or other laboratory setting or in combination with industry experience is acceptable.
• Ideally, the candidate should also have demonstrable competency in directing exploratory toxicology studies and working as a toxicology project leader on discovery project teams.
• The candidate should possess strong skill sets related design and implementation of investigative toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic translational toxicology studies, with a particular emphasis on comparative biology.
• The individual should have a creative mindset and interest in developing strategies and directing innovative approaches to measure target modulation in (normal tissues) including genetic and pharmacological validation tools.
• Expertise in comparative immune modulation (animals and human) and a keen interest in understanding adverse effects derived from modulation of the immune surveillance pathways and understanding regulation of innate and acquired immunity in normal tissues is a plus.
• Experience with leveraging and integrating gene expression and genomics data as well as cellular approaches to identify and advance programs is desired.
  • A related expertise is demonstrable capability in innovative techniques emerging from organotypic, in vitro systems and genetic modification. Experience with gene manipulation editing (RNAi, CRISPR) or image analysis is a plus.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.