Research Associate I, Biology (Protein Sciences)
- Employer
- MyoKardia, Inc (acquired by BMS)
- Location
- Brisbane, California, United States
- Start date
- Sep 2, 2020
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- Discipline
- Science/R&D, Biology, Research
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
We are seeking a knowledgeable and self-motivated Research Associate to join our Protein Sciences Group within the company's Research Division. In this laboratory-based position, the successful candidate will work to purify a diverse repertoire of proteins for the company's drug discovery efforts, contributing to compound screening and mechanism characterization pipelines. The candidate should be capable of designing, executing, and troubleshooting experiments independently, bringing enthusiasm and creativity to their work.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Purification of a wide variety of native and recombinant proteins, working with multiple source materials (muscle, yeast, bacteria, etc.)
- Characterization of protein samples to determine parameters such as purity, activity, and recovery
- Documentation of experimental data, maintaining well organized laboratory records, and presentation of findings at group or department meetings
- Ensuring efficient laboratory operations: preparing stock solutions and other reagents, managing lab inventories, maintenance and troubleshooting of equipment
- Collaborating with other team members and taking initiative to identify problems and improve procedures
EDUCATION/EXPERIENCE/SKILLS:
- BS in biochemistry, molecular biology or related field. 3-5 years of applicable experience is a plus
- Proficient with chromatographic purification systems (e.g. AKTA) and affinity, ion-exchange, hydrophobic, and size-exclusion chromatography
- Experience with batch purification techniques (precipitation, filtration, ultra-centrifugation, etc.) and cell disruption (e. g. microfluidization)
- Experience with protein characterization techniques such as SDS-PAGE, Western blot, SEC-HPLC, spectroscopy, and enzyme kinetics
- Excellent laboratory skills. Ability to generate accurate, reproducible, and actionable data.
- Good interpersonal, communication, and presentation skills
Company
MyoKardia’s mission is to change the world for people with serious cardiovascular disease through bold and innovative science. MyoKardia is a clinical-stage bio pharmaceutical company discovering and developing targeted therapies for the treatment of serious cardiovascular diseases. The company is pioneering a precision medicine approach to its discovery and development efforts by 1) understanding the bio mechanical underpinnings of disease; 2) targeting the proteins that modulate a given condition; 3) identifying patient populations with shared disease characteristics; and 4) applying learnings from research and clinical studies to inform and guide pipeline growth and product advancement. MyoKardia’s initial focus is on small molecule therapeutics aimed at the proteins of the heart that modulate cardiac muscle contraction to address diseases driven by excessive contraction, impaired relaxation, or insufficient contraction. Among its discoveries are three clinical-stage therapeutics: mavacamten (formerly MYK-461); danicamtiv (formerly MYK-491) and MYK-224. Founded in September 2012 MyoKardia is headquartered in Brisbane, CA.
- Website
- http://www.myokardia.com/
- Phone
- 650-741-0900
- Location
-
1000 Sierra Point Parkway
Brisbane, CA 94005
US
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