Bristol Myers Squibb Company

Principal Scientist, Computer-Assisted Drug Design

Location
Redwood City, CA, United States
Posted
Sep 01, 2020
Ref
R1529056
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking an exceptional scientist to join the Computer-Assisted Drug Design team. As part of our team, you would utilize structure-based and ligand-based computational chemistry methods together with machine learning to design molecules with superior pharmacological properties. You will be expected to proactively generate testable hypotheses, design/execute complex computational experiments, provide in-depth analysis and interpretation of results, and translate them into actionable molecular designs that advance the discovery portfolio. Through close collaboration, clear communication, and technical excellence, you will work with scientists across the R&D organization to influence the pipeline from target identification and modality selection through to candidate nomination.

Responsibilities will include, but are not limited to, the following:
  • Influence the prospective use of computational methods in rigorously evaluating therapeutic targets, modalities and agents within project teams.
  • In close collaboration with project teams and using multiple modalities, apply a wide variety of drug-design and computational chemistry methods to improve potency, selectivity, and ADME properties while minimizing toxicological risk and pro-actively influence decision making on project teams.
  • Enhance understanding of SAR and influence team strategy by assimilating and interpreting data using modeling and data-mining technologies.
  • Apply and develop new approaches for designing bioactive-relevant features using multi parameter optimization methods.
  • Provide scholarship in early target space vis-à-vis competitive information, literature/patent reviews and mining, chemical matter feasibility assessment, target feasibility/modality assessment, druggability/binding site characterizations, as appropriate.
  • Maintain and develop working knowledge of contemporary computational chemistry methods and their application to drug discovery projects.


Background Requirements:
  • A completed Ph.D. in computational chemistry or a related field with strong application background as demonstrated by contributions to leading journals
  • A minimum of 8- years of relevant professional experience.
  • Expertise in a subset of computational methods: docking methods, molecular dynamics simulations, homology modeling approaches, free energy simulations, machine learning techniques, large-scale data visualization/analysis and multiple parameter optimization methods and a familiarity with the rest.
  • Experience in applying computational methods to diverse biological targets such as different protein families, DNA, RNA using different modalities such as traditional modulators, allosteric modulators, covalent agents, chimeric protein degraders, molecular glues, antibodies, antibody-drug conjugates is preferred.


Scientific/Technical/Functional Skills:
  • Demonstrated skills in the application of computer-assisted drug design using standard modeling and computational software packages
  • Demonstrated ability to independently analyze literature and project data, formulate creative design hypotheses, data analysis and design novel agents in the context of project need.
  • Ability to serve as a lead computational chemist on multiple drug discovery projects and be accountable for delivery of project goals
  • A working knowledge of medicinal chemistry and drug discovery
  • Basic programming experience in at least one scripting language (e.g., Perl, Python) or programming language (Java, C, C++)
  • Excellent communication and organizational skills and ability to work within a multidisciplinary team across geographic areas to advance discovery projects are required
  • Personal attributes of integrity, creativity, problem solving, and strong work ethic


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.