Bristol Myers Squibb Company

Senior Scientist, Product Sciences

Location
Seattle, WA, United States
Posted
Aug 31, 2020
Ref
R1527025
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

PURPOSE AND SCOPE OF POSITION:

The Cell Therapy Product Sciences department is seeking a Senior Scientist to support the development of early stage CAR T and engineered TCR cell products. The Product Sciences Team is responsible for developing and executing mechanism of action and characterization studies to support the development of gene-engineered T cell therapies.The primary focus of the Senior Scientist - Product Sciences role will be to build eTCR and CAR T cell product and process understanding in support of pipeline projects. Successful candidates will have a strong foundation in human T cell biology and experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays. This role will lead a small team in a matrixed environment and requires a demonstrated ability to lead cross-functional teams and independently design and execute studies to meet project goals.

DUTIES AND RESPONSIBILITIES:
  • Design and deploy in-depth characterization of gene engineered T cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and additional cutting edge analytical techniques.
  • Participate and lead cross-functional teams to support the development of gene engineered T cell therapeutic platforms.
  • Identification and prioritization of novel analytical approaches for interrogating gene engineered T cell function.
  • Develop and maintain relationships with external collaborators and service providers.
  • Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions.
  • Author, review, and approve technical documents, including methods, protocols, reports, and SOPs
  • Learn and apply ICH/FDA/EMEA guidance and current thinking.


REQUIRED COMPETENCIES: Knowledge, Skills, and Abilities:

Education:

Senoir Scientist: PhD and 5+ years in Biology, Cell Biology, Immunology, or relevant discipline

Experience

Qualifications and Education Requirements
  • Prior success in managing small, high performing teams
  • Proven ability collaborate in a fast paced environment, meet deadlines, & prioritize work on multiple projects.
  • Excellent interpersonal, written and verbal communication skills, and attention to detail
  • Expertise in human T cell biology and in vitro modulation of T cell differentiation and function with small molecules and/or biologics.
  • Experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function - including multi-parameter flow cytometry, T cell functional assays, and gene expression platforms
  • Strong verbal and written skills.


Preferred Qualifications
  • Demonstrated experience in leadership roles providing scientific mentorship.
  • Understanding of cell signaling pathways involved in memory T cell differentiation.
  • Experience authoring regulatory documents, including IND and BLA filings.
  • Track record of successful internal and external scientific collaborations.


WORKING CONDITIONS (US Only):
  • Office and laboratory environments with a mix of natural and LED lighting with low level of background noise. Required computer and conferencing hardware are provided. 40% seated at a desk with ergonomic and sit/stand desks and 60% time in meetings.
  • Local, national, and international travel up to 5%


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.