Bristol Myers Squibb Company

Scientist or Senior Scientist, Product Sciences

Seattle, WA, United States
Aug 31, 2020
Required Education
Bachelors Degree
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.


The Cell Therapy Product Sciences department is seeking a Scientist/ Sr. Scientist to support the development of gene engineered T cell products. The Product Sciences Team is responsible for developing and executing mechanism of action and characterization studies to support the development of gene-engineered T cell therapies.The primary focus of the Scientist/Senior Scientist - Product Sciences role will be to build CAR/TCR T cell product and process understanding in support of early and late stage CAR T. Successful candidates will have a strong foundation in human T cell biology and other immune cell types. Experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays is critical. This role is highly collaborative and requires a demonstrated ability to lead cross-functional teams and independently design and execute studies to meet project goals.

  • Design and deploy in-depth characterization of gene engineered T cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and additional cutting-edge analytical techniques.
  • Participate and lead cross-functional teams to support the development of gene engineered T cell therapeutic platforms.
  • Support product-related impurities understanding including experimental design and execution, writing technical reports, and presenting data
  • Identification and prioritization of novel analytical approaches for interrogating gene engineered T cell function.
  • Develop and maintain relationships with external collaborators and service providers.
  • Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions.
  • Perform and manage instrument and method troubleshooting
  • Author, review, and approve technical documents, including methods, protocols, reports, and SOPs
  • Learn and apply ICH/FDA/EMEA guidance and current thinking.

REQUIRED COMPETENCIES: Knowledge, Skills, and Abilities:


Scientist: BS and 10+ years/MS and 8+ years/ PhD and 0-2+ years in Biology, Cell Biology, Immunology, or relevant discipline

Senior Scientist: PhD and 5+ years in Biology, Cell Biology, Immunology, or relevant discipline


Qualifications and Education Requirements
  • Proven ability collaborate in a fast paced environment, meet deadlines, & prioritize work on multiple projects.
  • Excellent interpersonal, written and verbal communication skills, and attention to detail
  • Expertise in human T cell biology and in vitro modulation of T cell differentiation and function with small molecules and/or biologics.
  • Demonstrated expertise with multi-parameter flow cytometry and gene expression platforms
  • Demonstrated independence in experimental design, data analysis, interpretation, and presentation.

Preferred Qualifications
  • Experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function.
  • Experience with genome-wide expression platform implementation and analysis, microarray, NanoString, RNA-seq, or other.
  • Understanding of cell signaling pathways involved in memory T cell differentiation.
  • Demonstrated experience in leadership roles providing scientific mentorship.
  • Experience authoring regulatory documents, including IND and BLA filings.
  • Track record of successful internal and external scientific collaborations.

  • Office and laboratory environments with a mix of natural and LED lighting with low level of background noise. Required computer and conferencing hardware are provided. 40% seated at a desk with ergonomic and sit/stand desks and 60% time in laboratory or meetings.
  • Local, national, and international travel up to 5%
  • This job description is intended to describe the general nature and level of work being performed by the person assigned to this position. The primary duties and responsibilities are intended to describe those functions that are essential to the performance of this job.
  • This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. There are other duties and responsibilities that are considered incidental or secondary to the overall purpose of this job. Employees holding this position will be required to perform any other job-related duties as requested by management.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.