Associate Scientist (CAR Cell Therapies & Antibody Platform Dev.)

Location
Tarrytown, NY, United States
Posted
Aug 30, 2020
Ref
17189BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Associate Scientist innovatively designs engineered immune cell therapies from comparison against novel antibody biologics. This individual supports the preclinical development of adoptive cell therapies, antibodies, and novel immune activating proteins through their design, molecular cloning, and expression. We are looking for someone who can proactively perform both in vitro and in vivo tumor studies to examine mechanisms of action.

In this role, a typical day might include the following:

- Independently design, clone, and express novel immunostimulatory proteins in cell lines and primary immune cells
- Developing in vitro assays to characterize protein function in either innate immune cells (phagocytosis) or lymphocytes in order to validate mechanisms of action
- Performing gene editing, imaging (fluorescence, confocal) of antigen presenting cell function, and multiparameter flow cytometry (cell lines, primary human immune cells, and cells isolated from tumor mice)
- Organizing and conducting anti-tumor efficacy studies in mice including dosing (IV, IP, SC) and tumor growth monitoring
- Compiling results and findings across experiments and programs then presenting to multi-functional teams, including senior management
- Analyzing data using biological and statistical software such as FlowJo, Prism, Excel, etc.
- Potentially manage Research Associates as needed

This role may be for you if:

- You have a deep understanding of immunological principles
- You are a highly organized problem-solver able to clearly communicate insights to colleagues and teams
- You efficiently prioritize while coordinating multiple projects

To be considered for this opportunity, you must have a PhD with a focus in immunology and cell therapy fields combined with a strong publication record. Experience in cell culture (primary and cell lines), enriching and expanding primary T cells and APC, an isolating and maturing innate immune cells from mouse and human PBMC samples to characterize cell phenotype and functions. We need someone with detailed knowledge of multiparameter flow-based assays, general biochemical, cellular, and molecular assays, and lentiviral vectors. We are searching for a candidate who has hands on experience using CRISPR/Cas9 and characterization of antibody conjugates is valuable.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

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