Research Scientist, Analytical Operations

Employer
Kite Pharma
Location
Santa Monica, CA, United States
Posted
Aug 28, 2020
Ref
R0015018
Required Education
Doctorate/PHD/MD
Position Type
Full time
Kite is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the health and safety of our teams.

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job

Job Description

We are seeking a talented and highly motivated immunologist with strong experience in immune cell profiling by flow cytometry and/or expertise in other related cell-based approaches, such as CyTOF mass cytometry, ImageStream cell imaging, and/or cell sorting. The Research Scientist will be responsible for identifying attributes associated with product manufacturability in alignment with Process Development objectives. They will lead the design of flow cytometry-based biomarker assays that will be used from early stage development through commercialization. The data from these assays will be used to establish critical quality attributes (CQAs) and to enhance manufacturing process understanding and design. This work will be applicable to the development of control systems and characterization strategies and to inform specifications for Kite's CAR and TCR programs.

The Research Scientist will collaborate cross-functionally with Process Design, Research, Translational Medicine, and/or Quality teams in an effort to enable in-process attribute and product understanding. The ideal candidate should be adaptable and willing to accept new roles and responsibilities that could evolve over time.

Responsibilities include but are not limited to:
  • Multi-parameter flow cytometry method design and demonstrated application to interrogating functional phenotype of T cell subsets
  • Handling and maintenance of associated materials, such as cells and reagents, in an established and controlled manner
  • Generation, analysis, interpretation, documentation and presentation of experimental data
  • Author, review, and edit technical documents, i.e. SOPs and/or reports
  • Participate in meetings, present data, and provide expertise in areas of responsibility
  • Provide technical guidance and mentorship to junior staff

Qualifications
  • Ph.D in Biology, Immunology, Cancer Biology or related discipline with 0+ years of industry experience, M.S. in Biology, Immunology or related discipline with 6+ years of industry experience, or B.S. in Biology, Immunology or related discipline with 8+ years of industry experience
  • Advanced knowledge of cell biology, cancer biology, and immunology preferred
  • Expertise in multi-color flow cytometry technology and associated instrumentation such as the BD Canto, Cytoflex S/LX and/or other platforms
  • Knowledge and experience in flow cytometry data analysis including CytExpert, FACSDiva, FlowJo and/or other relevant software
  • Knowledge of mammalian cell culture including primary T cells
  • Experience in cell sorting, CyTOF mass cytometry and ImageStream cell imaging is a plus
  • Proficient in the use of Microsoft Office, data analysis software (e.g. Prism, JMP) and other applications
  • Strong scientific writing and presentation skills
  • Ability to think critically and demonstrate troubleshooting and problem-solving skills
  • Highly collaborative with excellent interpersonal, verbal and written communication skills
  • Self-motivated, detail-oriented, and willing to accept temporary responsibilities outside of initial job description
  • Comfortable in a fast-paced small company environment with minimal direction


Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.