Scientist, Protein Therapeutics

Location
San Francisco, CA, United States
Posted
Aug 28, 2020
Ref
5235-187-R
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Position Overview

Nektar has an exciting opportunity for a Scientist, Protein Therapeutics to join their Protein Chemistry Team.

Responsible for preparing and purifying protein PEG conjugates, writing reports and maintaining detailed laboratory documentation. Designs, develops and applies methods for the production and characterization of polymer-conjugated proteins and peptides for human therapeutic use. Participates in large molecule drug discovery. Participates and occasionally leads in the execution of scientific research and/or product development activities. Applies scientific principles and concepts to potential inventions, products and problems. Plans and executes laboratory research/experimentation. Maintains broad knowledge of state-of-the-art principles and theories. Makes contributions to scientific literature, conferences and/or understanding of company processes. This job contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs.

Works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors. Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions. Normally receives no instructions on routine work, general instructions on new assignments. Responsible for hands on PEGylation and purification of proteins and peptides, development/execution of purification schemes for PEG-conjugates, and development/execution of analytical methods for PEG-conjugate analysis. Methods may also be developed for LCMS or CE. Write technical reports, contribute to patents applications and team meetings, and coordinate activities with other team members. Oral presentations will be periodically required. Synthesizes multiple data sources and draws general, non-obvious conclusions. Defines problems, develops approaches and develops experiments with sound judgment with minimal supervision. Uses professional concepts and scientific knowledge to contribute to the development of company concepts and principles to achieve objectives in creative and effective ways. Acts as a principal investigator in conducting own experiments. Participates in the development of patent applications. Interfaces with various departments, customers and partners. Puts work practices in context with larger team. Coordinates activities with other team members. Writes complex reports and protocols. May assist with implementing organizational systems, identifying capital equipment, and projecting near-term resource requirements.May lead a small group, providing training as needed, and ensures adherence to company policies and quality requirements.

A PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 2 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Must be able to demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought. Must be current in field, while able to demonstrate expert knowledge in scientific principles and concepts. Familiarity with IEX, RP, and SEC and standard laboratory techniques is expected. Prior experience of protein conjugation is preferred. Expertise with LC/MS is highly desirable. Previous experience in protein purification, HPLC method development and standard biochemical laboratory techniques required. Must be able to clearly communicate scientific information both written and oral with minimal assistance. Must be able to compose sound written work with no assistance. Must possess good oral & written communication skills. Must be able to demonstrate sound judgment. Must be able to demonstrate problem solving capabilities. Strong organizational skills are required. Good computer skills are required. Working knowledge of MS word, Excel, Power point is a plus. Experience working in an FDA regulated environment and knowledge of current GMPs as they apply to laboratory practices are highly desired.Previous supervisory skills are a plus. Must be willing to work as part of a team.Must be able to demonstrate good interpersonal skills.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.