Sr. Research Associate - DMPK

Location
Hayward, CA, United States
Posted
Aug 27, 2020
Ref
132
Discipline
Science/R&D, Research
Hotbed
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Arcus Biosciences is seeking a highly motivated and team-oriented individual for the position of Senior Research Associate in the Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful candidate will be responsible for conducting in-vitro ADME profiling and Metabolite ID studies, to support multiple drug discovery and development projects.

Responsibilities include, but are not limited to:
  • Perform in vitro ADME assays such as metabolic stability, plasma protein binding, CYP inhibition and reaction phenotyping; develop new assays as needed.
  • Conduct in vitro metabolite identification studies using LC-HRMS/MS.
  • LC-MS/MS method development and quantitative analysis of small molecules in various biological matrices.
  • Perform data analysis and reporting of experimental results to project teams.
  • Operation, maintenance and troubleshooting of LCMS instruments.


Qualifications:
  • BS/MS degree in chemistry or related scientific discipline with 3-5 years of relevant industry R&D experience.
  • Solid background in organic chemistry, and good knowledge of DMPK principles.
  • Hands-on experience with in vitro ADME assays and LC-MS/MS method development are required.
  • Experience with Thermo Orbitrap and liquid handling systems would be a plus.
  • Strong work ethic, self-motivated, attention to detail, and proven ability to work both independently and collaboratively in a team environment.
  • Excellent communication and writing skills.