Scientist, Biologics Development

Irvine, CA, United States
Aug 27, 2020
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description

Envision working with energetic colleagues and inspirational leaders. Now, place yourself in that mix; leading discussions, asking the right questions and driving results.

What Your New Manager Wants You To Know

The Scientist, purification will be an instrumental team member of the Biologics Development Process Sciences Department, based in Irvine, CA. The primary role of the scientist, purification is to execute of all aspects of purification process development, process scale up and GMP manufacturing support. Particularly, the position is responsible for independently plan, design, and executes the experiments and develops processes to support the purification of natural and recombinant proteins (including neurotoxin and antibodies) from bacterial as well as mammalian cell cultures at small and intermediate scale during various stages of development.

The scientist in this position is expected to possess a clear understanding and in-depth knowledge and experience including but not limited to: chromatography processes, ultrafiltration/diafiltration, process characterization and optimization, process scale up, scale down model qualifications and validation. The ability to demonstrate a significant level of hands on experience in several of these areas is expected. Additional responsibilities include data analysis, troubleshooting process and equipment, participation in project teams, lab inventory and organization, maintaining detailed records of batches and experiments.

This position also requires a desire and ability to work as an integral part of a team and supporting drug discovery teams as well as demonstrate a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of position.

Furthermore, the position requires the individual to work with and in areas requiring select agents and Toxins access (i.e. Biosafety level 2 and biosafety level 3 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with AbbVie internal and applicable regulatory requirements. AbbVie internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements and objectives.

YOU ARE more than just a title, YOU ARE...

A strategic thinker: align and excite internal stakeholders to facilitate success through strong leadership, strategic thinking and personal drive.

First class team player: collaborate across multiple disciplines to ensure compliance and ability to influence cross-functional teams and senior leadership.

You Will

  • Have hands on laboratory bench work to develop and prepare biologics products candidates for various groups with tight timelines.
  • Independently operate and have sound knowledge of AKTA pure and AKTA Ready chromatography systems. Position requires proficient knowledge and hands on experience of clarification equipment as well.
  • Conduct routine down-stream purification operations relating to AKTA chromatography system prep: assembly/disassembly, in process sampling and media/buffer/reagent prep and able to troubleshoot operational and equipment issues.
  • Be willing to work with and handle potent neurotoxins and in-process samples that contain neurotoxin and neurotoxin expressing organisms. Ability to perform all operation and manipulation under a biosafety laminar flow hood.
  • Follow study protocols and execute experiments independently (or minimal supervision) at small scales and large scale.
  • Demonstrate technical competence in executing purification experiments utilizing detailed knowledge of standard analytical techniques in purification process development and data analysis.
  • Author and edit development batch records and associated standard operating procedures. Compile experimental batch records and documents/inventory for in-process samples in the inventory system.
  • Have additional responsibilities are lab inventory and organization. Individual will evaluate lab equipment and procure the necessary supplies to ensure continual successful lab operations.
  • Assist purification team in tech transfer for process developed at small scale to early stage process development laboratory (internally or externally).
  • Complete training consistent with safety, technical, operational, process, and other skill/ knowledge requirements for the position. Maintain all training to current status. Support safety program and ensure safety in all routine and new operations by strictly following SOPs.



You Bring
  • PhD in Biological Science, Biochemistry, Protein Chemistry, Biochemical/Chemical Engineering or a related Life Science field with 0-2 years of relevant industrial experience or MS with 2+ years or BS with 4+ years of related work experience.
  • Hands-on experience in the operation of purification AKTA chromatography system is required.
  • Extended knowledge of chemical principles applicable to protein purification.
  • Demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought

In this role, we're looking for a leader who will :
  • Act as an Owner
  • Be Excellence Focused
  • Act as an Influencer

Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.