Bristol Myers Squibb Company

Scientist or Senior Scientist, Product Sciences - Cell Therapy

Location
Celgene, NJ, United States
Posted
Aug 27, 2020
Ref
R1528906
Required Education
Bachelors Degree
Position Type
Full time
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Summary:

As part of the Product Sciences group, the energetic and motivated Sr. Scientist /Scientist will have responsibility for leading design, execution and interpretation of complex experiments/studies related to the development of new/enhanced knowledge regarding CAR T cell products, intermediates, starting materials, manufacturing processes and analytical tools within a CMC technical development function. The Sr. Scientist/Scientist role may act as both a team lead and independent contributor to achieve program, platform and functional objectives in collaboration within technical development and across Clinical, Cellular Immuno-Oncology, Informatics and Translation research teams.

Responsibilities will include, but are not limited to, the following:
  • Contribute to and lead the development of biological hypotheses relating to product cellular attributes and their impact on clinical outcomes, manufacturing and development of analytical tools
  • Lead technical development of sensitive bioanalytical assays to characterize cell products, intermediates and starting material
  • Develop and execute complex characterization strategies relating to clinical and non-clinical product development
  • Develop and contribute to informatics-based correlative studies supporting identification of critical product attributes
  • Support CMC objectives by providing biological and technical knowledge across program and platform strategies for product, process and analytical development
  • Efficiently organize data and share findings within and across teams
  • Drive building of general knowledge within cell therapy development function and maintain awareness of competitive landscape in the cellular immune-oncology space
  • Mentor, support and empower the development of junior scientists as it relates to both technical and strategic elements of cell therapy product development
  • Ensure proper operation and perform routine maintenance of all laboratory equipment
  • Maintain a safe workplace in accordance with company and OSHA policies/procedures


Skills/Knowledge Required:
  • B.S. or M.S. in Immunology, Cell/Molecular Biology, Biomedical Engineering or related discipline with 7-10 academic and/or industrial experience for Scientist or 10+ years academic and/or industrial experience for Sr. Scientist
  • Ph.D. in Immunology, Cell/Molecular Biology, Biomedical Engineering or related discipline with 0-3 years of academic and/or industrial experience for Scientist or 3-5 years of academic and/or industrial experience for Sr. Scientist
  • Demonstrated ability to lead functional and matrix teams towards achieving objectives and deliverables on time with high quality (Require for Sr. Scientist; nice to have for Scientist)
  • Strong desire to work within a team structure and to develop, mentor and coach team members leading to their success, engagement and growth is required
  • Ability to work under minimal technical supervision, perform technical, strategic and operational tasks independently and lead complex and cross-functional activities
  • Extensive experience in mammalian cell culture techniques, including isolation of immune cell subsets, maintenance and expansion of primary cells and cell lines is required
  • Advanced knowledge of basic techniques in immunology, cell biology and molecular biology is required. Experience with FACS, immunofluorescence-based assays, ELISA, PCR, cytokine and chemokine detection, cell-based bioassays is highly desired
  • Experience with analytical method development for a variety of cell-based bioassays, binding assays and/or residual impurities assays is preferred
  • High motivation and drive to acquire new skills and knowledge is desired
  • Willingness to work in a regulated industrial environment.
  • Excellent verbal and written communication skills


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.