Scientist, In Vivo Pharmacology

Employer
Pfenex
Location
San Diego, CA
Posted
Aug 25, 2020
Required Education
Doctorate/PHD/MD
Position Type
Full time

Pfenex Drug Discovery Team is seeking a highly motivated, talented, detail-oriented Scientist with hands-on in vivo Pharmacology and PK/PD experience to support novel target discovery and drug development.  

Essential Duties and Primary Responsibilities

  • Develop in vivo models for multiple indications including but not limited to cancer, hemolysis, inflammation, cardiovascular, and endocrine disease areas.
  • Design, execute and analyze in vivo experiments to support novel therapy product development, test therapeutic hypotheses and build new mouse models and technology platforms for Pfenex’s target therapies.
  • Conduct in vivo studies to evaluate pharmacokinetic, pharmacodynamic, tolerability and mechanism of action of drug candidates.
  • Provides expertise in multi-species PK study designs with a high understanding of species differences, dose routes and prediction of drug candidates using different scientific approaches.
  • Perform drug administration (IP, SC and IV), bleeding, imaging and tissue collection.
  • Culture primary and immortalized cells.
  • Analyze blood and tissues using a battery of cell and molecular biology techniques (histology, flow cytometry, DNA/RNA/Protein, etc.)
  • Analyzes data, keeps meticulous records and maintains notebooks in accordance of company guidelines
  • Maintains laboratory equipment and performs general laboratory duties as required  
  • Prepares study reports and appropriate sections of the common technical documents for regulatory submissions and queries on development candidates.
  • Potentially interacts with health authorities (e.g., FDA, etc.)

Job Skills, Abilities, and Qualifications

  • DVM or PhD in Pharmacokinetics, pharmacology, or related field of Biomedical Sciences with a minimum of 3 years industry experience in large molecule/biologics drug development
  • Exceptional non-PhDs with at least 7 years industry experience and demonstrated capabilities may also be considered
  • Ability to develop focused in vivo strategies and utilize PK/PD/efficacy data to drive lead optimization & characterization as well as translational strategies to enable early clinical development.
  • Strong animal handling skills and hands-on in vivo pharmacology skills, including preparation of test compounds, dosing (oral, IV, IP), blood and tissue collection for PK and PD biomarker analysis.
  • Extensive surgical skill in rodents with more than one therapeutic area is a plus.
  • Knowledge of and experience with relevant PK/PD software applications, such as WinNonLin, is a desire.
  • Hands-on histology experience is a plus.
  • Proven track record of working with CROs and academic labs.
  • Proficiency in Microsoft Office and GraphPad Prism required.
  • Excellent organizational skills, able to multi-task and excited for hand-on laboratory research.
  • Excellent oral and written communication skills.
  • Must be a team player and perform at a high level in a matrixed drug discovery environment.
  • Level will be commensurate with experience.

Additional Information

  • Affirmative Action and Equal Opportunity Employer (EOE)
  • No agencies or phone calls please
  • Pfenex celebrates the diversity of life and welcomes all individuals to apply
  • Must be legally authorized to work in the US without sponsorship