Research Investigator II

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

The Nonclinical Research and Development (NCRD) has an opening for a Research Investigator, II in New Brunswick, NJ.

A highly motivated and critically thinking Research Investigator in the Department of Immuno- and Molecular Toxicology will be responsible for designing, justifying, developing, implementing, and conducting various immunological, molecular and cellular biology based in vitro and ex vivo assays, as well as directing in vivo or in vitro studies that address the toxicologic, immunotoxicologic and/or pharmacodynamic potential of compounds in development. In addition, the qualified candidate will participate on investigative project teams aimed at addressing key scientific and/or project-related questions including mechanistic toxicology concerns across the portfolio. This position involves evaluation of recent literature and new technology, assessment and implementation of new experimental techniques/approaches, significant problem-solving efforts, as well as presentation and defense of experimental approaches and data to key stake holders.

Responsibilities:

• Be a key leader in the design, development, validation, and conduct of immunologic, biochemical, and molecular biology‑based assay systems that address the toxicologic and/or pharmacodynamic potential of compounds in development, as well as assays to investigate mechanisms of toxicity across the portfolio. As appropriate, this person communicates and defends results of experimental testing in presentation formats, meetings, internal reports and/or external publications.
• Design and develop in vitro and ex vivo laboratory procedures/assays to support programs across the portfolio, using a broad range of experimental platforms and high-end technologies. Establish procedures for experimental techniques, and conduct laboratory procedures/assays in compliance with established protocols, often according to regulatory and standard laboratory requirements. This person will use a broad range of experimental platforms including ex vivo or in vitro analysis of the function/phenotype of a variety of cell types, complex cell culture/tissue systems, multiplexing technology, flow cytometry, polymerase chain reaction, confocal microscopy, biochemical assays, ELISA and many others, as appropriate.
• Share scientific expertise within Drug Safety Evaluation and across BMS organizations to facilitate successes in drug development portfolio wide, as well as participate in external scientific and regulatory discussions.
• Play a key role in group laboratory meetings and participate in data analysis and interpretation/summary discussions, and troubleshooting of scientific and technical issues initiated by self and colleagues.
• Prepare or revise test methods and standard operating procedures and maintain equipment and data and equipment documentation under guidelines set forth by SOPs and, when appropriate, GLP regulations.

Requirements:

• A Ph.D. degree and Postdoctoral experience in Immunology, Pharmacology, Toxicology, Molecular and Cell Biology, or other related bioscience. A deep understanding of the immune system and immune cell signaling is preferred.
• Hands-on experience with molecular and cell biology techniques including experience in flow cytometry, ELISA, functional tissue and cell-based assays, nucleic acid isolation, and polymerase chain reaction. The candidate should also have experience working with animal models and in vitro tissue-based models.
• Must be able to work independently and possess a high level of self-motivation and determination with a strong aptitude in method development and critical scientific thinking. In addition, must have a PASSION for working in a team setting and driving robust science.
• Must have good written and verbal communication skills.
• Individual must be able to manage multiple research activities, provide and accept input on data interpretation, foster a spirit of team effort, and be able to work well with others.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.