Our clinical research institute partner is seeking a talented and motivated Postdoctoral Fellow, who will focus on the development of novel diagnostic, prognostic, and predictive biomarkers for various gastrointestinal cancers.
Key Responsibilities include:
- Exploration of cell-free and circulating DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal).
- Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
- Study the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in various GI malignancies.
- Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers
- Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells.
- The role of tumor microenvironment, immune regulation and identification of various targeted therapies (e.g. immune checkpoint inhibitors) in GI cancers.
- The role of exosomes as biological determinants, and exosomal cargo as disease biomarkers
- Gut microbiome and its influence in gastrointestinal cancers
Basic education, experience and skills required for consideration:
- PhD and/or MD/PhD.
- Evidence of first author peer-reviewed publications.
- Prior molecular, cancer biology and/or translational research experience and evidence of project development.
Preferred education experience and skills:
- Relevant experience in cancer genetics and epigenetics.
- Prior hands-on experience in developing cell-free DNA and RNA-based, liquid biopsy assays in cancers.
- Preference will be given to individuals who had previous experience with microarray and next generation sequencing-based platforms (MiSeq, HiSeq, NovaSeq, RRBS, ChIP-Seq, MeDip etc.).
- Strong background in biochemistry and/or molecular biology, as well as experience in identification and development of therapeutic targets in cancer (CRISPR/Cas-9, high-throughput target screens etc.).
- Desire to grow and develop skills in order to become an independent Investigator.
- Possess excellent communication and writing skills.
- Enthusiastic and highly motivated.
- Able to think creatively and independently.
- Possess good organizational skills.
- Able to work independently and in a team environment.