Postdoctoral Fellow

Location
San Gabriel Valley
Posted
Aug 18, 2020
Required Education
Doctorate/PHD/MD
Position Type
Full time

Our clinical research institute partner is seeking a talented and motivated Postdoctoral Fellow, who will focus on the development of novel diagnostic, prognostic, and predictive biomarkers for various gastrointestinal cancers. 

 

Key Responsibilities include:

  • Exploration of cell-free and circulating DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal).
  • Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
  • Study the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in various GI malignancies.
  • Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers
  • Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells.
  • The role of tumor microenvironment, immune regulation and identification of various targeted therapies (e.g. immune checkpoint inhibitors) in GI cancers.
  • The role of exosomes as biological determinants, and exosomal cargo as disease biomarkers
  • Gut microbiome and its influence in gastrointestinal cancers

Basic education, experience and skills required for consideration:

  • PhD and/or MD/PhD.
  • Evidence of first author peer-reviewed publications.
  • Prior molecular, cancer biology and/or translational research experience and evidence of project development.

Preferred education experience and skills:

  • Relevant experience in cancer genetics and epigenetics.
  • Prior hands-on experience in developing cell-free DNA and RNA-based, liquid biopsy assays in cancers.
  • Preference will be given to individuals who had previous experience with microarray and next generation sequencing-based platforms (MiSeq, HiSeq, NovaSeq, RRBS, ChIP-Seq, MeDip etc.).
  • Strong background in biochemistry and/or molecular biology, as well as experience in identification and development of therapeutic targets in cancer (CRISPR/Cas-9, high-throughput target screens etc.).
  • Desire to grow and develop skills in order to become an independent Investigator.
  • Possess excellent communication and writing skills.
  • Enthusiastic and highly motivated.
  • Able to think creatively and independently.
  • Possess good organizational skills.
  • Able to work independently and in a team environment.