Principal Scientist, In Vivo Pharmacology

Principle Scientist In-Vivo Pharmacology
South San Francisco, CA
 
This position will afford the successful individual a unique opportunity to develop innovative drugs to treat ocular diseases. The candidate will lead pharmacology efforts and be a key contributor in setting up the strategy for target identification and validation based on an emerging and exciting biology.
 
The successful candidate will be a strong individual contributor and team leader with experience managing and developing research associates and junior scientists. She/he should be motivated by exciting science, be highly innovative with appetite for risk taking, possess first-hand experience advancing programs in a Discovery organization, have team leadership experience, and have relevant industry experience ranging from early discovery, target identification, lead optimization, translational pharmacology, to IND submission.
 
Responsibilities will include overseeing the in vivo strategy including the selection/development/validation of in vivo models that focus on understanding the pharmacodynamic activity and translation to disease-relevant efficacy. The duties of the job include experimental design and execution, analysis and interpretation of data, management of internal reports/resources, coordination of CRO deliverables, and regular presentation (verbal/written) of results and interpretation at group, project team, and Discovery team meetings.
 
REQUIREMENTS:

• PhD. with >8 years of scientific experience or Bachelor's/Master's degree with >10 years in the biopharmaceutical industry. Degree in Pharmacology, Physiology, or a related field is essential.
• In-depth drug discovery experience in ocular diseases in an industry setting. Small or large molecule experience.
• Track record developing in vivo ocular models of disease is required. Knowledge and experience operating laboratory instruments in ocular disease.
• Experience writing IND sections and reports to support regulatory filings.
• Evidence of independent scientific ability (g.,post-doctoral training) and a track record of scientific accomplishments through publications, patents, and invited presentations.
• Experience with immunohistochemistry, quantitative PCR, flow cytometry, fluorescence microscopy and a variety of detection technologies (radiometric, colorimetric, luminescence, fluorescence, imaging and label-free methods, etc.).
• Ability to manage complexity and ambiguity in a highly matrixed work environment.
• Track record of managing, developing, and mentoring junior scientists and research associates.
• Creativity and the ability to lead and/or work within an interdisciplinary team in order to achieve technical and corporate milestones.
• Robust experimental design and troubleshooting skills, and excellent data analysis/mining/statistics capabilities.