Frederick National Laboratory for Cancer Research

Bioinformatics Analyst I/II - MoCha

Frederick, MD, USA
May 23, 2020
Required Education
Bachelors Degree
Position Type
Full time
The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha's major activities include development and application of genomic assay platforms for use in DCTD-sponsored national clinical trials and preclinical studies.

This is a Dual Level Req for a Bioinformatics Analyst I or Bioinformatics Analyst II. Either level may be filled with this req.


  • Validate and maintain genomic analysis pipelines for exome, whole genome and RNA-seq data generated from the mocha lab and/or collaborator(s) and help provide biological interpretation of the genomic analysis to advance the understanding of cancer
  • Responsible for the organization and management of large genomic datasets, and the integration of data from multiple sources
  • Collaborate with other bioinformatics team members to ensure the quality of work and the prioritization of projects to meet deadlines
  • Interacts with management to define strategies for genomic data analysis including hypothesis generation and testing of predictive biomarkers of drug response
  • Interacts extensively with intramural laboratories at the NIH and extramural scientists
  • Responsible for generating scientific opinions, identifying potential resources or constraints, and proposing strategies for exploiting available databases and program data generated at the molecular and cellular levels


Possession of a Bachelors Degree in biomedical science/bioinformatics/math/statistics/computer-related field from an accredited college or university. Foreign degrees must be evaluated for U.S. equivalency

Bioinformatics Analyst I: No additional work experience is required beyond a related Bachelor's degree.

Bioinformatics Analyst II: In addition to the education requirements, a minimum of two (2) years of related computational experience in a biological/medical research laboratory environment with a strong background in bioinformatics application development
  • Experience in analysis of next generation sequencing (NGS) data (including quality metrics, mapping, variant calling, quantitation of gene expression and biological interpretation)
  • Experience in analysis of large genomic data sets including integration with data available from public or private sources
  • Hands-on experience in data processing and analyzing sequencing and expression and other array data including quality and biological assessment are also essential
  • Experience in a computer cluster environment
  • Proficiency in bash shell scripting and in one or more of the programming languages such as R, C/C++, PYTHON, PERL, JAVA, SQL and bioinformatics tools and database management
  • Experience and demonstrated success in a team-oriented environment and excellent communication skills (written and oral)
  • Ability to identify and solve complex problems
  • Ability to obtain and maintaining a security clearance

This position is essential to the success of MoCha and on-site presence in Frederick, MD and occasionally in Shady Grove (Rockville, MD) is required.

  • Experience in algorithm development for NGS data analysis.
  • In-depth understanding of molecular biology techniques, oncology and clinical research.
  • Experience in data integration, database construction, application development and visualization.
  • Experience in porting applications to a web environment and working with workflow tools and applications are also desired.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)