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Bioinformatics Analyst IV

Employer
Frederick National Laboratory for Cancer Research
Location
Frederick, MD, USA
Start date
Apr 8, 2020

View more

Discipline
Science/R&D, Bioinformatics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
BioCapital

Job Details

The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha's major activities include development and application of genomic assay platforms for use in DCTD-sponsored national clinical trials and preclinical studies.

This position is essential to the success of MoCha and on-site presence in Frederick, MD and occasionally in Shady Grove (Rockville, MD) is required.

KEY ROLES/RESPONSIBILITIES
The Bioinformatics Analyst IV serves as the technical authority on computational issues related to the assigned projects/programs.

Duties include:
  • Validate and maintain genomic analysis pipelines for exome, whole genome and RNA-seq data generated from the mocha lab and/or collaborator(s) and help provide biological interpretation of the genomic analysis to advance the understanding of cancer
  • Responsible for the organization and management of large genomic datasets, and the integration of data from multiple sources
  • Supervise and collaborate with other bioinformatics team members to ensure the quality of work and the prioritization of projects to meet deadlines
  • Interacts with management to define strategies for genomic data analysis including hypothesis generation and testing of predictive biomarkers of drug response
  • Interacts extensively with intramural laboratories at the NIH and extramural scientists
  • Responsible for generating scientific opinions, identifying potential resources or constraints, and proposing strategies for exploiting available databases and program data generated at the molecular and cellular levels

BASIC QUALIFICATIONS
  • Possession of a Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a related field (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the education requirements, a minimum of eight (8) years of related computational experience in a biological/medical research laboratory environment with a strong background in bioinformatics application development is required
  • Must possess experience in analysis of next generation sequencing (NGS) data (including quality metrics, mapping, variant calling, quantitation of gene expression and biological interpretation)
  • Experience in analysis of large genomic data sets including integration with data available from public or private sources
  • Hands-on experience in data processing and analyzing sequencing and expression and other array data including quality and biological assessment are also essential
  • Experience in a computer cluster environment is required
  • Proficiency in bash shell scripting and in one or more of the programming languages such as R, C/C++, PYTHON, PERL, JAVA, SQL and bioinformatics tools and database management is essential
  • Must be proficient in several genomic data analysis tools such as GATK, Samtools etc., as well as biological pathway/functional analysis
  • Expertise in statistical analysis of complex biological data is critical to success
  • Experience and demonstrated success in a team-oriented environment and excellent communication skills (written and oral) are also required
  • Ability to identify and solve complex problems. Proven knowledge of cancer biology demonstrated through peer reviewed publications is required
  • Must be able to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS
  • Experience in algorithm development for NGS data analysis. In-depth understanding of molecular biology techniques, oncology and clinical research
  • Experience in data integration, database construction, application development and visualization
  • Experience in porting applications to a web environment and working with workflow tools and applications are also desired

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

Company

A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take

 

 

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Company info
Website
Phone
301-846-1000
Location
8560 Progress Drive
Frederick
MD
21701
US

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