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Senior Scientist I/II

Employer
AbbVie
Location
Cambridge, MA, US
Start date
Mar 30, 2020

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

Description:

AbbVie is investing heavily in a new research enterprise in Cambridge, Boston - the Foundational Neuroscience Center (FNC). The FNC is investigating the fundamental biological mechanisms underpinning neurodegenerative diseases, initially Alzheimer's disease. We are now growing our research remit to take advantage of shared disease mechanisms, building a new research team focused on Parkinson's disease (PD) to discover and develop disease-modifying therapeutics for this devastating disease!

We are seeking a highly motivated Senior Scientist with expertise in neurodegenerative diseases and a background in biochemistry/biophysics to join the Parkinson's Biology Area team! As a key member of our team, you will develop methods to produce pathogenic aggregates from synthetic proteins and purify protein aggregates from various tissues. Following generation and purification you will structurally characterize these aggregates before use in in vitro and in vivo models of PD.

Key Responsibilities Include:

  • Establish strong scientific and technical initiatives and hands-on implementation for the purification and generation of pathogenic protein aggregates
  • Establish novel methods to characterize aggregate structures
  • Build a strong team with other members of the PD-group to execute biochemical and cell-based assays to support novel PD target validation
  • Execute projects through experimental designs, critical analysis and interpretation of results and communication of results promptly
  • Collaborate with cellular and molecular biologists, in vivo pharmacologists and medicinal chemists across global research sites
  • Present research at internal and external meetings, and publish in peer-reviewed journals


Level will be based on education and years of experience.

Qualifications (Sr. Sci I):

  • Bachelors, Masters, or PhD in Neuroscience or closely related field with typically 8+ (BS), 6+ (MS) or 0+ (PhD) years of experience; Pharmaceutical industry experience preferred


Qualifications (Sr. Sci II):

  • Bachelors, Masters, or PhD in Neuroscience or closely related field with typically 10+ (BS), 8+ (MS) or 2+ (PhD) years of experience; Pharmaceutical industry experience preferred


Additional:

  • Strong expertise in advanced biophysical/biochemical assays for protein aggregate purification and generation including differential centrifugation techniques, advanced microscopy techniques, protein detection & quantification (such as ELISA, MSD, plate readers), and enzyme kinetic assays; Experience in in vitro propagation of protein aggregates is preferred
  • Extensive bench research experience and enjoy a laboratory-focused role in a fast-paced, multidisciplinary team
  • Ability to design, execute and interpret experiments independently, and to advance scientific understanding
  • Excellent written and verbal communication; Strong interpersonal and teamwork skills
  • Strong organizational skills that enable multitasking and working within timelines

Company

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

Stock Symbol: ABBV

Stock Exchange: NYSE

Company info
Website
Phone
1-800-255-5162
Location
1 North Waukegan Road
North Chicago
Illinois
60064
US

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