Research Associate / Senior Research Associate, Biology (Microbiome)

The Research Associate/Senior Research Associate will be part of the Assembly Biosciences biology team at our South San Francisco site, and will report directly to the lead Scientist on multiple key projects within the microbiome program. As RA/SRA, you will work closely with the Scientist and other team members in executing cell-based assays, using biochemical assays to produce mechanistically relevant readouts, organizing and analyzing data to produce informative conclusions. You will also assist with in-vivo studies by working with mouse models to generate in-vivo and ex-vivo results. In this role, you will be given projects to lead independently that will have a high impact on the advancement of the program. Your efforts will directly impact the selection and the advancement of the potential therapeutics into clinical trials for patients.

If you are someone who likes to work in a collaborative team environment and is excited about changing the paradigm of microbiome research, this is the right position for you.

Key Responsibilities include:

• Cell culture including primary human and mouse cells with proper aseptic techniques
• ELISA/multiplex analyte assays
• Immunoblotting
• Immunohistochemistry
• Flowcytometry
• RNA isolation and Real-Time PCR
• Experimental planning and execution
• Data analysis with proper statistics
• Data organization and presentation
• Assist in mouse model experiments (in-vivo handling and ex-vivo processing)
• Maintain a good record of protocols and data to ensure the integrity and reproducibility of the data and results
• Problem-solve and trouble shoot to overcome unsuccessful experiments which is a big part of research
• Present your work to the team in order to stimulate novel ideas through group discussions

Preferred Qualifications:

• BA/BS in a biology-related scientific discipline with 2+ years of experience in biotech/pharmaceutical research. Candidates at the senior RA level should have 5+ years of experience
• Experience in basic research techniques and safe laboratory practices in a BSL2 environment
• Preference for previous training in the field of immunology
• Preference for previous hands on training working with experimental mouse models including tissue harvesting and processing
• Demonstrated track record of productivity and knowledge working with primary cell culture, flow cytometry and standard molecular biology techniques (including ELISA assays, reporter assays, (RT)qPCR and DNA/RNA isolation and handling)
• Desire and demonstrated ability to quickly develop new technical skills, ability to think independently, be results oriented and have strong attention to detail
• Experience with Microsoft Office programs with a desired knowledge of GraphPad Prism and FlowJo Software
• Ability to communicate effectively and present basic concepts and detailed scientific data to diverse teams through good verbal and written communication skills
• Ability to independently perform, troubleshoot and interpret experiments
• Ability to prioritize and deliver results with a strong emphasis on quality, detail, documentation, technical rigor, and timely delivery
• Highly motivated, proactive, and able to work well in a fast-paced team environment

About Assembly Bio

Assembly Biosciences (NASDAQ: ASMB) is a clinical-stage biotechnology company developing innovative therapeutics targeting hepatitis B virus (HBV) and diseases associated with the microbiome. The HBV program is focused on advancing a new class of potent, oral core inhibitors that have the potential to increase cure rates for chronically infected patients. The microbiome program is developing novel oral live microbial biotherapeutic candidates with Assembly Bio's fully integrated platform, including a robust process for strain identification and selection, GMP banking and production, and targeted delivery to the lower gastrointestinal tract with the GEMICEL ® technology.

We believe our Microbiome platform represents a best in class approach to developing biopharmaceutical agents from live biotherapeutic products. ABI-M201, our lead program in mildly to moderately active ulcerative colitis (UC), is currently in a phase 1b clinical trial. This program is part of a broader collaboration we established with Allergan in 2017 for gastrointestinal programs such as UC, Crohn's disease and Irritable Bowel Syndromes. Our internal pipeline comprises first in class or best in class live microbial biotherapeutic approaches in areas such as oncology, immune mediated and metabolic disorders, and other areas of high medical need.

We pride ourselves on creating a culture and work environment that is scientifically driven, ambitious, and collaborative. We encourage diversity of thought that leads to great innovation and are looking to add to our dynamic team of great people who are driven to transform the lives of patients.

Assembly Bio is headquartered in Carmel, Indiana, while the R&D headquarters is in South San Francisco. The Company also has a microbiome manufacturing facility in Groton, CT, and offices in China. Assembly Bio has a strong balance sheet having raised approximately $166 million in July 2018. We are positioned well to build the next phase of the Company toward global development and commercialization of our innovative medicines in HBV-cure and the Microbiome.

AAP/EEO Statement
Assembly Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. We are committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV status, sexual orientation, gender identity and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status protected by the laws or regulations in the locations where we operate. We will not tolerate discrimination or harassment based on any of these characteristics.