Scientist, Cancer Immunotherapy

Description:

Fate Therapeutics is seeking a highly motivated Immunologist with expertise in immune oncology to join a multidisciplinary team dedicated to the discovery of novel cellular therapeutics for the treatment of hematological disorders and solid tumors. The ideal candidate will have in-depth knowledge of NK or T cell biology in addition to extensive experience with mammalian cell culture. Experience with current molecular biology techniques used for editing and engineering of lymphocytes is a plus. This position will be a key member of our cancer immunotherapy team and will assist in performing and analyzing studies involving in vitro, in vivo, and ex vivo testing of Fate Therapeutics’ novel cellular therapy products. This is a full-time, bench-level position reporting to a Senior Scientist in Cancer Immunotherapy and is located at the Company’s corporate headquarters in San Diego, California.

Responsibilities:

• Optimization of protocols for the production and expansion of highly-edited CAR-T cells

• Transduction and electroporation of primary T cells

• Assessment of CAR-T phenotype through multi-parameter flow cytometry

• Assessment of CAR-T function using standard in vitro assays looking at proliferation, cytokine secretion, and target cell killing

• Oversee and/or execute in vivo experiments with support from the in vivo core

• Support programs at Fate in the areas of tumor immunology and cellular immunotherapies

• Interpret data and present to the immediate working group and to larger program-specific teams

Qualifications:

• Ph.D. degree in Immunology, Cancer biology, or other related fields with at least 3 years of post-doctoral experience

• In-depth experience with multi-parameter flow cytometry

• In-depth experience in mammalian cell culture

• In-depth experience in executing and developing assays involving primary human T-cells

• Experience with CRISPR screening in lymphocytes is a plus

• Experience with current molecular biology techniques for editing and engineering of T cells is a plus

• Experience with in vivo tumor model development is desirable

• Proven ability to coordinate with multiple researchers for scheduling and execution of complex experiments

• Excellent communication and organization skills are a must

• Positive outlook and a team-oriented attitude

Working Conditions and Physical Requirements:

• Will require working with cells and cell lines of human and/or animal origin

• Will require working with hazardous materials

• 100% on-site work at corporate headquarters in San Diego, CA

• Evening and weekend work as necessary The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.