VP, Pharmacology & Toxicology
- Employer
- AnaptysBio, Inc.
- Location
- San Diego, CA, US
- Start date
- Nov 13, 2019
View more
- Discipline
- Science/R&D, Pharmacology, Toxicology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach
Job Details
This position reports to the Chief Medical Officer.
Some responsibilities include:
- Crafting the pre-clinical and clinical pharmacological strategies, including dose escalation, contributing to stopping rules, and risk-benefit to ascertain that compounds are entered into man safely, efficiently and with scientific validity.
- Overseeing the development and validation of quantitative in vivo assays to enable pharmacological characterization of therapeutic antibodies
- Establishing collaboration with CROs and/or academic institutions to develop in vivo pharmacology models to permit progression into the clinic of therapeutic antibodies
- Providing strategic and tactical direction to multiple project teams
- Preparing study reports for regulatory submission on development candidates
- Contributing to new project ideas and in vivo proof-of-concept studies to enable the initiation of new antibody projects
- Leading the Development project team and oversee the transition from discovery to clinical development of new antibodies
Requirements
Education & Experience
- PhD in Pharmacology or related science with a minimum of 15 years' experience in a drug-discovery setting of a biopharmaceutical company, accompanied by at least 5 years of proven leadership experience.
- Extensive experience in developing quantitative in vivo pharmacodynamic assays and preclinical disease models to assess target engagement and efficacy in a range of inflammatory/autoimmune conditions
- Proven track record of making major contributions to the discovery of one or more marketed or in-development medicines
- Prior experience of working across diverse therapeutic areas is highly desirable
- Sound theoretical and experimental background in biology coupled with a solid foundation in quantitative pharmacology
Skills & Knowledge
- Expert knowledge of pharmacokinetics, toxicology, and formulation
- Ability to perform randomized controlled clinical trial principles, methodology and procedures
- Skilled at statistical data collection, editing, validation and analysis techniques
- Proven managerial competence with previous experience in directly managing teams
Company
AnaptysBio is a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics. We are developing immune cell modulators, including two checkpoint agonists in clinical-stage development, for autoimmune and inflammatory disease: rosnilimab, our PD-1 agonist program in a Phase 2 trial for the treatment of moderate-to-severe rheumatoid arthritis; and ANB032, our BTLA agonist program, currently in a Phase 2b trial for the treatment of moderate-to-severe atopic dermatitis. Our preclinical immune cell modulator portfolio includes ANB033, an anti-CD122 antagonist antibody for the treatment of autoimmune and inflammatory diseases. In addition, AnaptysBio has developed two cytokine antagonists available for out-licensing: imsidolimab, an anti-IL-36R antagonist, in Phase 3 for the treatment of generalized pustular psoriasis, or GPP, and etokimab, an anti-IL-33 antagonist for the treatment of respiratory disorders that is Phase 2/3 ready. AnaptysBio has also discovered multiple therapeutic antibodies licensed to GSK in a financial collaboration for immune-oncology, including an anti-PD-1 antagonist antibody (Jemperli (dostarlimab-gxly)), an anti-TIM-3 antagonist antibody (cobolimab, GSK4069889) and an anti-LAG-3 antagonist antibody (GSK4074386).
Our corporate vision is to transform patient health by delivering innovative immunology therapeutics. Find out more about us by following us on Twitter.
CONNECT
- Website
- http://www.anaptysbio.com/
- Phone
- 858-362-6295
- Location
-
10770 Wateridge Circle
Suite 210
San Diego
California
92121
United States
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