Senior Scientist I/II, Protein X-ray Crystallographer

Lake County, IL, US
Nov 10, 2019
Required Education
Bachelors Degree
Position Type
Full time
Our Protein Crystallography Group located in Lake County, Illinois is seeking a scientist with extensive hands on experience in modern Xray Crystallography techniques and computational methods of molecular structure analysis to join our StructureBased Drug Discovery team! As a member of our multidisciplinary team, you will utilize fragmentbased strategies to identify ligands and provide insight to advance drug discovery targets through structurebased design. Additionally, you will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.

Key Responsibilities:
  • Determine Xray crystal structures of proteinligand complexes in high throughput modes and identify strategies for improved molecular designs
  • Support the crystallization and protein construct design efforts for useful sample preparations
  • Utilize Cheminformatics tools and manipulate scripts for use across mixed computing platforms
  • Collaborate with members of Fragmentbased Drug Discovery team to advance hit to lead projects
  • Work with biologists, molecular modelers, and medicinal chemists to validate targets of interest
  • Maintain accurate and timely records of experimental results
  • Communicate results and interpretative analysis to project teams and present at internal meetings
  • Publish in peer reviewed journals as appropriate and present at external scientific meetings
  • Evaluate the scientific literature critically and embrace novel technologies which will facilitate structurebased drug discovery at AbbVie

Position will be hired based on level of experience.
  • Bachelors, Masters or PhD in Chemistry, Biochemistry, Biophysics, or a related field with typically 10-12+ (BS) 8-10+ (MS) or 0-4+ (PhD) or more years of relevant academic or industry experience
  • Proven ability in protein crystal structure analysis with Xray or Electron Diffraction data
  • Familiarity with structure based drug design strategies and fragment based approaches; detail oriented and meticulous regarding documentation and data management
  • Work both independently and as part of a highly collaborative, interdisciplinary team
  • Effective written and verbal communication skills
  • Ability to work on multiple projects in parallel and rapidly adjust to changing priorities

Preferred Qualifications:
  • Experience in complementary techniques of macromolecular SAXS analysis or CryoEM

Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.