Staff Scientist - Synthetic/Oligonucleotide Chemistry

Tarrytown, NY
Nov 09, 2019
Required Education
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

The successful candidate will lead oligonucleotide conjugation chemistry, purification, and characterization of oligo conjugates and other chemistries. The scientist will be required to independently assist in all aspects of design and synthesis of small molecules for conjugate use and rationally implement the knowledge gained from iterative rounds of medicinal chemistry to drive projects forward.


• Design and implement novel conjugation and characterization methods involving oligonucleotides and other novel small molecules.

• Design and implement a variety of regio-selective conjugations, lead and perform conjugation, purification, and characterization of conjugates for preclinical in vitro and in vivo studies.

• Design and implement novel oligonucleosides for solid phase synthesis.

• Drive projects forward using successive rounds of medicinal chemistry.

• Collaborate with cross-functional research teams and external CRO teams to prioritize and deliver conjugates from screening to candidate selection.

• Lead efforts in technology transfer related to conjugation/purification/analysis from discovery to process development.

• Prepare presentations and communicate conjugation and characterization efforts to related project teams.

Experience with the following additional skills and experience is a plus:

• Solid-phase oligonucleotide synthesis

• On or off bead oligo functional group conversion chemistries

• Large scale conjugation and characterization to support pilot toxicology studies

• Protein engineering and expression in bacterial and eukaryotic systems

This position requires a Ph.D. in chemistry and at least 7 years of industry experience in the conjugates/small molecule field.

• Extensive research experience and knowledge to design and develop novel conjugates and conjugation methods.

• Hands on experience with conjugation, purification and characterization of conjugates, and experience using analytical techniques/instruments, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC, SDS-PAGE, UV-Vis, mass spectroscopy, and NMR.

• Effective written and verbal communication


This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.