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Scientist I/II, Biochemistry and Chemical Biology

Employer
Revolution Medicines
Location
94063, Redwood City
Start date
Nov 9, 2019

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Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time

The Opportunity:

As a member of the Biology Dept and a key player in the Chemical Biology/Biochemistry team, you will:

  • Apply diverse technologies in the laboratory to illuminate the functional roles and mechanisms of action of key proteins in cancer signaling pathways, in particular the RAS pathway.
  • Characterize mechanisms of covalent and non-covalent enzyme inhibitors and small molecule modulators of protein interactions in cells and cell-free systems.
  • Develop cutting edge tools or probes to better understand target biology and guide drug candidate discovery.
  • Collaborate with colleagues in Discovery Technologies and Medicinal Chemistry to provide data-driven guidance to interdisciplinary teams to influence early stage program decisions.

Required Experience, Skills, and Education:

  • Ph.D. in Biochemistry, Chemical Biology, Molecular Biology, or related discipline (Scientist I).
  • 3+ years Postdoctoral or relevant industry experience (Scientist II) considered but not necessary.
  • Strong track record of research productivity with high quality, impactful publications.
  • Practical experience applying diverse biochemical, biophysical and/or chemical biology methods to quantitatively characterize enzyme mechanisms, cellular signaling pathways, or other complex biological processes.
  • Prior expertise in cancer signal transduction pathways, including RAS-MAPK, would be an advantage.
  • Skilled in quantitative data analysis, particularly nonlinear curve fitting and rigorous statistical validation of models.
  • Rigorous, quantitative, and detail-oriented experimentalist with a desire to continue in a laboratory-focused role.
  • Excellent written and verbal communication skills.
  • Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.
  • Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high energy, small company environment.

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