Skip to main content

This job has expired

You will need to login before you can apply for a job.

Scientist - Immunology/Inflammation Target Discovery and Validation

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, NY
Start date
Oct 26, 2019

View more

Discipline
Science/R&D, Immunology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Pharm Country, Best Places to Work

Job Details

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
This position within the Immunology and Inflammation Area is for a rigorous scientist with preferred experience in autoimmunity and/or allergy, B cell biology and disease models driven by pathogenic antibodies. Candidate should be highly collaborative and team-driven, possess exceptional organizational skills and be capable of independently conducting in vitro and in vivo experiments. This individual will have the opportunity to support a broad pipeline in autoimmune and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules in disease models, and interrogating mechanisms of pathology that inform therapeutic strategies.

Responsibilities:

• Contribute to project advancement by developing new methods and technologies

• Troubleshoots methodological and technical issues, interprets experimental data and literature, and communicates results to supervisor, department, or project team.

• Executes experiments based on projects/protocols provided and works towards independently developing project

• Collaborates and communicates efficiently with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts

• Experience with proper handling and care of mice, general surgical techniques and the collection of blood and tissue samples.

• Develops and optimizes relevant disease mouse models and the subsequent analysis of associated disease-related pathologies by flow cytometry, histology and ELISA

• Develops and executes cell based assays to screen candidate antibodies for various research programs

• Performs ELISAs and or MSDs to measure cytokine levels and determine antigen binding for various research programs

• Extensive experience with multi-parameter Flow cytometry and data analysis is required. Candidate will present analyzed data to supervisor and team.

• Basic computer literacy and experience collecting and analyzing biological data on the computer is a necessity.

• Contribute to lab and equipment maintenance and order supplies/reagents to help create a safe, effective and efficient working environment.

Requirements:
Qualified applicants will have a Ph.D. in Biology, Immunology, or Cellular and Molecular Biology and at least 3-5 year of academic or 2-4 years of industry post doc experience in immunology

• The ideal candidate will be skilled in the design of complex studies to interrogate the in vivo efficacy of novel therapeutics and thus, will have experience with developing and optimizing mouse models of autoimmune and/or allergic diseases and the subsequent analysis of associated disease-related pathologies by flow cytomety, histology and ELISA.

• Knowledge of autoimmune and allergic diseases, B-cell and plasma cell biology is preferred

• Must have experience conducting studies utilizing flow cytometry as well as the design of panels, analysis of data and interpretation of findings.

• Preferred experience developing and optimizing primary cell assays used to characterize cytokine and immunoreceptor pathways and screen antibody candidates is preferred.

• Preferred experience with the following data analysis programs:
GraphPad PRISM, Softmax Pro, FlowJo analysis, HALO, DIVA software

• Must have a record of high quality publications in scientific literature.

• The candidate is expected to have effective oral communication and written skills.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

FacebookTwitterInstagramYouTube Logo

Company info
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert