Senior Human Geneticist - CV, Metabolic,Musculoskeletal
- Employer
- Regeneron Pharmaceuticals, Inc.
- Location
- Tarrytown, NY
- Start date
- Oct 26, 2019
View more
- Discipline
- Science/R&D, Biostatistics, Biotherapeutics, Research, Genetics, Epidemiology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
Summary:
We are looking for a talented Human Genetics scientist to join our Cardiovascular, Metabolic and Musculoskeletal Therapeutic Area Genetics team. The position will take on responsibilities for the design, execution, and interpretation of genetics studies focusing on cardiovascular, metabolic, and musculoskeletal diseases, as part of the Therapeutic Area Genetics team. The post holder will work closely with Clinical Informatics, Analytical Genomics and other teams in the Regeneron Genetics Center. Primary responsibilities will be to lead genetics discovery projects, support new programs and collaborations, and to support the execution of overall scientific strategy in cardiovascular, metabolic and musculoskeletal disease genetics. Goals of the team will be to apply genetics to target discovery, select indications for drug programs, and identify subgroups of patients who are more likely to respond to treatment through genetic analyses.
Responsibilities:
• Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other team members to design, execute, and interpret genetics studies related to in cardiovascular, metabolic and musculoskeletal diseases for the RGC.
• Work in close collaboration with other Therapeutic Area Genetics team members and form a strong partnership with Analytical Genomics, Clinical Informatics and other RGC teams to deliver on complex, top-quality scientific endeavors in these Therapeutic Areas.
• Generate, summarize, and present results in internal and external meetings to a variety of audiences. Lead or contribute to the writing of scientific reports and publications.
• Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC and Regeneron.
• Collaborate with external industry and academic partners in scientific consortia.
Requirements:
• PhD in Genetic Epidemiology, Statistical Genetics (with an applied focus), Human Genetics or similar with good analytical skills.
• 2-4 years of experience or corresponding level of achievement in the field of large-scale human genetics post PhD.
• Demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries in a team-based environment.
• Familiarity and experience with different genetic association approaches including GWAS, exome or genome sequencing in cohort, case-control or family-based studies. Ability to use large genetic datasets such as UK Biobank or other large biobanks, TOPMed, GWAS summary statistics, GTEx or similar.
• Familiarity and experience with the applications of statistical genetics to gain medically-actionable insights, including conditional analyses, fine-mapping, quantitative traits analyses and Mendelian randomization. Ability to analyze complex loci, use gene-specific and genome-wide polygenic scores, or perform genetic studies that simulate randomized controlled trials.
• An outstanding candidate will have experience with the use of genetics in combination with other "omics" technologies (eg. metabolomics, proteomics, RNA-seq).
• Familiarity with command line interface, programming languages and statistical software (eg. Python, R, STATA), statistical genetics tools (eg. PLINK) and large-scale data platforms (eg. DataBricks, Scala).
• Interest in understanding the genetic basis and causes of Cardiovascular, Metabolic and Musculoskeletal diseases and translating this knowledge into therapeutic insights. An outstanding candidate will have previous experience with cardiovascular, metabolic or musculoskeletal phenotypes.
• Ability to work in a highly interactive environment with a diverse team of colleagues.
• Outstanding communication skills and an ability to summarize and present the results of human genetic studies to a variety of audiences.
• A commitment to high-quality science and to the highest standards of research and work ethics and integrity
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Company
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
Stock Symbol: REGN
Stock Exchange: NASDAQ
- Website
- https://www.regeneron.com/
- Phone
- 914-847-7000
- Location
-
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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